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ChemicalBook >> CAS DataBase List >>2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-

2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-

2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Structure
2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- structure
CAS No.
454234-24-3
Chemical Name:
2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-
Synonyms
JAK3-IN-14;JAK3-IN-14, 10 mM in DMSO;2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-;(3Z)-5-(pyridin-3-yl)-3-[(1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one
CBNumber:
CB99106281
Molecular Formula:
C18H13N3O
Molecular Weight:
287.32
MDL Number:
MOL File:
454234-24-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Properties

Boiling point 607.1±55.0 °C(Predicted)
Density 1.332±0.06 g/cm3(Predicted)
pka 12.26±0.20(Predicted)
form Solid
color Yellow to orange
FDA UNII 5KU2EZ77LX

2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0890211 JAK3-IN-14 99.32% 454234-24-3 5mg $596 2026-06-04 Buy
ChemScene CS-0890211 JAK3-IN-14 99.32% 454234-24-3 10mg $867 2026-06-04 Buy
aablocks AA01I61U 3-((1H-Pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one 98+% 454234-24-3 25mg $101 2026-05-30 Buy
aablocks AA01I61U 3-((1H-Pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one 98+% 454234-24-3 50mg $171 2026-05-30 Buy
aablocks AA01I61U 3-((1H-Pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one 98+% 454234-24-3 100mg $290 2026-05-30 Buy
Product number Packaging Price Buy
CS-0890211 5mg $596 Buy
CS-0890211 10mg $867 Buy
AA01I61U 25mg $101 Buy
AA01I61U 50mg $171 Buy
AA01I61U 100mg $290 Buy

2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Chemical Properties, Uses, Production

Uses

JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1].

Definition

ChEBI: 5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one is a member of indoles.

IC 50

JAK3: 38 nM (IC50); JAK2: 600 nM (IC50)

References

[1] Chen JJ, et al. Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5633-8. DOI:10.1016/j.bmcl.2006.08.022

2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Suppliers

Global Suppliers ( 14)
Supplier Tel Email Country ProdList Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9778 55
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Beijing Boorsen Biotechnology Co., Ltd 400-901-9800 18611424007 cis@bioss.com.cn China 9185 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 025-5885952 15955137747 sales@aikonchem.com China 8012 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 ivan@atkchemical.com China 32997 60
Supplier Advantage
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
TargetMol Chemicals Inc. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Beijing Boorsen Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 58
Shanghai Amole Biotechnology Co., Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60

View Latest Price from 2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JAK3-IN-14 pictures 2026-07-27 JAK3-IN-14
454234-24-3
 $107.00-397.00 99.39% 10g TargetMol Chemicals Inc.
  • JAK3-IN-14 pictures
  • JAK3-IN-14
    454234-24-3
  • $107.00-397.00
  • 99.39%
  • TargetMol Chemicals Inc.

2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- Spectrum

2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-(454234-24-3)1HNMR

454234-24-3 (2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)-) Related Search:

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2H-Indol-2-one, 1,3-dihydro-5-(3-pyridinyl)-3-(1H-pyrrol-2-ylmethylene)- JAK3-IN-14 (3Z)-5-(pyridin-3-yl)-3-[(1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one JAK3-IN-14, 10 mM in DMSO 454234-24-3