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1-methyl-4-nitrosopiperazine

1-methyl-4-nitrosopiperazine structure

CAS No.: 16339-07-4

Chemical Name:: 1-methyl-4-nitrosopiperazine

Synonyms: Nsc523886;n-methyl-npz;-nitrosopiperazine;Olanzapine impurity 32;NITROSOMETHYLPIPERAZINE;Methylnitrosopiperidine;Levofloxacin Impurity 40;N-NITROSOMETHYLPIPERAZINE;N-METHYLNITROSOPIPERAZINE;NITROSO-N-METHYLPIPERAZINE

CBNumber:: CB9927630

Molecular Formula:: C5H11N3O

Molecular Weight:: 129.16

MDL Number:: MFCD01702457

MOL File:: 16339-07-4.mol

MSDS File:: SDS

Last updated:2026-05-28 05:11:02

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1-methyl-4-nitrosopiperazine Properties

Boiling point	239.23°C (rough estimate)
Density	1.1508 (rough estimate)
refractive index	1.5070 (estimate)
storage temp.	-10 to -25°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Oil
pka	6.50±0.42(Predicted)
color	Clear Light Yellow
Stability	Light Sensitive
Major Application	pharmaceutical small molecule
InChI	InChI=1S/C5H11N3O/c1-7-2-4-8(6-9)5-3-7/h2-5H2,1H3
InChIKey	CEAIOKFZXJMDAS-UHFFFAOYSA-N
SMILES	N1(C)CCN(N=O)CC1
FDA UNII	5584MPJ7F2
UNSPSC Code	12352200
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS05,GHS06
Signal word	Danger
Hazard statements	H314-H350-H301
Precautionary statements	P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501
target organs	Eyes,Central nervous system
WGK Germany	WGK 2
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Carc. 2 Eye Irrit. 2 Flam. Liq. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 1
Toxicity	LD50 orl-rat: 100 mg/kg ZEKBAI 69,103,67

1-methyl-4-nitrosopiperazine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M3750	1-Methyl-4-nitrosopiperazine min. 95.0 %	16339-07-4	250MG	$120	2026-04-30	Buy
Cayman Chemical	40300	N-Methyl-N’-nitrosopiperazine ≥95%	16339-07-4	10mg	$43	2026-04-30	Buy
Cayman Chemical	40300	N-Methyl-N’-nitrosopiperazine ≥95%	16339-07-4	50mg	$140	2026-04-30	Buy
Cayman Chemical	40300	N-Methyl-N’-nitrosopiperazine ≥95%	16339-07-4	100mg	$237	2026-04-30	Buy
Cayman Chemical	40300	N-Methyl-N’-nitrosopiperazine ≥95%	16339-07-4	250mg	$323	2026-04-30	Buy

Product number	Packaging	Price	Buy
M3750	250MG	$120	Buy
40300	10mg	$43	Buy
40300	50mg	$140	Buy
40300	100mg	$237	Buy
40300	250mg	$323	Buy

1-methyl-4-nitrosopiperazine Chemical Properties, Uses, Production

Uses

N-Methyl-N’-nitrosopiperazine was used as a reagent in the organic synthesis of several compounds including that of (4-methoxyphenoxy)acetic and (3,4,5-trimethoxyphenoxy)acetic acid amides and hydrazides which display antimicrobial and anthelmintic properties and may act as potential neurotropic and cardiovascular agents. N-Methyl-N’-nitrosopiperazine also diplayed strong nasal carcinogenity and genotoxicity toward nasal cells.

Safety Profile

Poison by ingestion. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Many N-nitroso compounds are carcinogens. When heated to decomposition it emits toxic fumes of NOx. See also NNITROSO COMPOUNDS.

1-methyl-4-nitrosopiperazine Preparation Products And Raw materials

Raw materials

1-Methylpiperazine

Preparation Products

1-methyl-4-nitrosopiperazine Suppliers

Global Suppliers ( 86)

Supplier	Tel	Email	Country	ProdList	Advantage
https://www.shachemlin.cn/	68080707 15021879576	ming-jiao.wu@chemlin.com.cn	China	9312	58
Hubei Molcoo Biotechnology Co., Ltd	17320513646	anna@molcoo.com	China	4616	58
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Guangzhou Austine Biotechnology Co., LTD	15918640830 13268843209	1947181658@qq.com	China	9146	58
Okeanos Tech Co,. Ltd.	010-62651721 18610486005	minghui.yu@okeanos.com.cn	China	495	60
Chengdu Forest Science and Technology Development Co., Ltd.	18030648795 18030648795	sales@cdforestchem.com	China	1998	58
Quality Control Solutions Ltd.	0755-66853366 13670046396	orders@qcsrm.com	China	18188	56
Shanghai Xingui Biotechnology Co., Ltd.	15121041756	xingui2022@126.com	China	9954	58
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	15775	55
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9883	50

Supplier	Advantage
https://www.shachemlin.cn/	58
Hubei Molcoo Biotechnology Co., Ltd	58
Energy Chemical	61
Guangzhou Austine Biotechnology Co., LTD	58
Okeanos Tech Co,. Ltd.	60
Chengdu Forest Science and Technology Development Co., Ltd.	58
Quality Control Solutions Ltd.	56
Shanghai Xingui Biotechnology Co., Ltd.	58
Shanghai Macklin Biochemical Co.,Ltd.	55
Shanghai Kewel Chemical Co., Ltd.	50

View Latest Price from 1-methyl-4-nitrosopiperazine manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-19	Levofloxacin Impurity 40	5mg	95%+	1000mg	Guangzhou Tosun Pharmaceutical Ltd
2025-12-19	Nintedanib Impurity 31 16339-07-4	5mg	95%+	1000MG	Guangzhou Tosun Pharmaceutical Ltd
2025-12-16	Olanzapine impurity 32 16339-07-4	10mg	99%+ HPLC	1000	Moxin Chemicals

Levofloxacin Impurity 40
95%+
Guangzhou Tosun Pharmaceutical Ltd

Nintedanib Impurity 31
16339-07-4
95%+
Guangzhou Tosun Pharmaceutical Ltd

Olanzapine impurity 32
16339-07-4
99%+ HPLC
Moxin Chemicals

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n-methyl-npz 4-Methyl-1-nitrosopiperazine 1-methyl-4-nitrosopiperazine N-nitroso-N'-methylpiperazine NITROSO-N-METHYLPIPERAZINE 1-NITROSO-4-METHYLPIPERAZINE NITROSOMETHYLPIPERAZINE N-METHYLNITROSOPIPERAZINE N-NITROSOMETHYLPIPERAZINE Methylnitrosopiperidine Methylpiperazinenitrosamine N-Nitroso-N'-methylpiperazin Nsc523886 Piperazine,1-methyl-4-nitroso- -nitrosopiperazine Levofloxacin Impurity 40 N-Methyl-N’-nitrosopiperazine 1-methyl-4-nitrosopiperazine, MeNP5 N-Methyl-N’-nitrosopiperazine in methanol Olanzapine impurity 32 1-Methyl-4-nitrosopiperazine (MNP) Solution N-Nitroso Chlorcyclizine EP Impurity A (N-Nitroso Cyclizine EP Impurity A, N-Nitroso Cyclizine USP Related Compound A) N-Nitroso Chlorcyclizine EP Impurity A 16339-07-4