ビタミン A パルミテート,油性 化学特性,用途語,生産方法
外観
黄色～褐色, 液体
定義
本品は、パルミチン酸(*)とレチノール(*)のエステルである。参照表示名称：パルミチン酸, レチノール
溶解性
エタノールに溶けにくく、水にほとんど溶けない。
無機性値/有機性値
80/700
用途
ビタミンA定量用標準品。
化粧品の成分用途
皮膚コンディショニング剤
効能
ビタミンA補充薬, レチノイン酸受容体(RAR)作動薬
商品名
チョコラ (エーザイ); チョコラ (サンノーバ)
化学的特性
95.0-100.5% Absorbance @325 nm ≥0.85%
分布
肝の脂肪蓄積細胞
使用
vitamin A palmitate is known as a skin “normalizer.” It acts as an antikeratinizing agent, helping the skin stay soft and plump, and improving its water-barrier properties. Because of its impact on the skin’s water-barrier properties, it is useful against dryness, heat, and pollution. It is also an anti-oxidant and is suggested for use in sunscreens. Clinical studies with vitamin A palmitate indicate a significant change in skin composition, with increases in collagen, DnA, skin thickness, and elasticity. Vitamin A palmitate’s stability is superior to retinol.
一般的な説明
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Retinyl palmitate belongs to a category of compounds called retinoids, which are chemically similar to vitamin A. It exhibits a beneficial effect on vision, skin and immune function, inhibits cell proliferation and prevents cancer. It is an important dietary as well as a therapeutic compound.
安全性プロファイル
Mildly toxic by
ingestion. An experimental teratogen.
Experimental reproductive effects. Human
mutation data reported. When heated to
decomposition it emits acrid smoke and
irritating fumes.
純化方法
The palmitate is separated from retinol by column chromatography on water-deactivated alumina with hexane containing a very small percentage of acetone. It is also chromatographed on TLC silica gel G, using pet ether/isopropyl ether/acetic acid/water (180:20:2:5) or pet ether/acetonitrile/acetic acid/water (190:10:1:15) to develop the chromatogram. It is then recrystallised from propylene at low temperature (below -47o). [Beilstein 6 IV 4135.]
ビタミン A パルミテート,油性 上流と下流の製品情報
原材料
準備製品