インジルビン-3'-オキシム

インジルビン-3'-オキシム 価格 もっと(11)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC1813	インジルビン-3'-オキシム Indirubin-3'-oxime	160807-49-8	10mg	￥66000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01FLCM01923	インジルビン-3'-モノキシム Indirubin-3'-monoxime	160807-49-8	250mg	￥271300	2024-03-01	購入
Sigma-Aldrich Japan	I0404	インジルビン-3′-オキシム ≥98% (HPLC), solid Indirubin-3′-oxime ≥98% (HPLC), solid	160807-49-8	1mg	￥29800	2024-03-01	購入
Sigma-Aldrich Japan	I0404	インジルビン-3′-オキシム ≥98% (HPLC), solid Indirubin-3′-oxime ≥98% (HPLC), solid	160807-49-8	5mg	￥99300	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TRCI527500	Indirubin-3'-monoxime	160807-49-8	1mg	￥18900	2024-03-01	購入

インジルビン-3'-オキシム 化学特性,用途語,生産方法

説明

Indirubin-3’-oxime is a potent inhibitor of glycogen synthase kinase 3β (GSK3β; IC₅₀ = 22 nM). As GSK3β phosphorylates tau protein, indirubin-3’-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer’s disease-relevant sites. It also inhibits cyclin-dependent kinases (CDKs) at higher concentrations, including Cdk1/cyclin B (IC₅₀ = 180 nM), Cdk2/cyclin A (IC₅₀ ~500 nM), Cdk2/cyclin E (IC₅₀ = 250nM), Cdk4/cyclin D1 (IC₅₀ = 3.3 μM) and Cdk5/p35 (IC₅₀ = 100 nM). Indirubin-3’-oxime reversibly inhibits the proliferation of many cells types, arresting cycling in the G₂/M phase.

化学的特性

Dark Red Solid

使用

A potent inhibitor of GSK-3 (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10üM).

生物活性

Protein kinase inhibitor: inhibits cyclin-dependent kinases (IC 50 = 0.18-3.33 μ M) and GSK-3 β (IC 50 = 0.19 μ M). Inhibits CDK5- and GSK-3 β -mediated tau phosphorylation, a process over-active in Alzheimer disease states. Also inhibits AMPK, LCK and SGK. Induces cell cycle arrest and inhibits cell proliferation.

インジルビン-3'-オキシム 上流と下流の製品情報

原材料

準備製品

インジルビン-3'-オキシム 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Shandong Xiya Chemical Co., Ltd	13355009207 13355009207	3007715519@qq.com	China	18722	57
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4765	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58

160807-49-8(インジルビン-3'-オキシム)キーワード:

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• 160807-49-8
• 3-[1,3-DIHYDRO-3-(HYDROXYIMINO)-2H-INDOL-2-YLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE
• INDIRUBIN-3'-OXIME
• Indirubine-3'-oxime
• INDIRUBIN-3’-MONOOXIME
• Indirubin-3
• Indirubin-3-monoxime - CAS 160807-49-8 - Calbiochem
• 2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
• -monoxime
• Indirubin-3'-monoxime
• 3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one
• -oxime
• Indirubin-3′
• Indirubin-3''-monoxime, GSK3beta inhibitor. CDK inhibitor.
• Indirubin-3''-monoxime, 10 mM in DMSO
• Indirubin-3'-monoxime, GSK3beta inhibitor. CDK inhibitor.
• Indirubin-3'-monoxime, GSK3beta inhibitor. CDK inhibitor.
• Indirubin-3'-monoxime
• 3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol
• インジルビン-3'-オキシム
• インジルビン-3'-モノキシム
• インジルビン-3′-オキシム