アカデシン
アカデシン 物理性質
- 融点 :
- 214-215 °C
- 沸点 :
- 726.3±60.0 °C(Predicted)
- 比重(密度) :
- 2.06±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- H2O: >10 mg/mL
- 外見 :
- 粉
- 酸解離定数(Pka):
- 13.27±0.70(Predicted)
- 色:
- タン
- 由来生物:
- rabbit
- 水溶解度 :
- 2mg/mlでDMSOに可溶。水またはエタノールに1mg/ml未満で可溶
- 極大吸収波長 (λmax):
- 265nm(NaOH)(lit.)
- Merck :
- 14,16
- Specific Activity:
- 255-345nmol/min·mg
- 安定性：:
- 購入日から2年間安定です。 DMSO または蒸留水に溶解したこの溶液は、-20°C で 3 か月間保存できます。
- InChI:
- 1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1
- InChIKey:
- RTRQQBHATOEIAF-UUOKFMHZSA-N
- SMILES:
- NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N
- CAS データベース:
- 2627-69-2(CAS DataBase Reference)
- EPAの化学物質情報:
- 1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOOR1170T |
5-Amino-1-(beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide |
2627-69-2 |
250mg |
￥16800 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01APOOR1170T |
5-Amino-1-(beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide |
2627-69-2 |
1g |
￥36000 |
2024-03-01 |
購入 |
|
東京化成工業
|
A2528 |
5-アミノイミダゾール-4-カルボキサミド1-β-D-リボフラノシド >98.0%(HPLC)
5-Aminoimidazole-4-carboxamide 1-β-D-Ribofuranoside
>98.0%(HPLC) |
2627-69-2 |
50mg |
￥10500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SAB1306034 |
IgG fraction of antiserum, buffered aqueous solution
ANTI-AMPK ALPHA2(C-TERMINAL) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution |
2627-69-2 |
400μL |
￥89100 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
A9978 |
≥98% (HPLC), powder
AICAR ≥98% (HPLC), powder |
2627-69-2 |
5mg |
￥19600 |
2024-03-01 |
購入 |
アカデシン 化学特性,用途語,生産方法
外観
白色〜うすい褐色, 結晶〜粉末
溶解性
水に溶ける。
効能
抗悪性腫瘍薬, 血小板凝集抑制薬
使用上の注意
不活性ガス封入
化学的特性
Solid
使用
AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav
e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
定義
ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is
is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.
一般的な説明
Adenosine monophosphateprotein kinase (AMPK) activator 5-aminoimidazole-4-carboxamideribonucleotide(AICAR)modulates cellular energy. It regulates lipid and glucose metabolism, pro-inflammatory responses,cytokine production,cell proliferation and apoptosis. AICAR improves ischemia or reperfusion injury and kidney fibrosis in rats. It provides protection against acute tubular necrosis.
生物活性
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.
副作用
AICAR is an AMPK (adenosine 5′-monophosphate (AMP)-activated protein kinase) activator that has been shown to have significant endurance-enhancing effects and is banned for use as a doping agent by the World Anti-Doping Agency. Overactivation of AMPK, or activation in the wrong tissues, can lead to serious side effects, including neurodegeneration or preventing cell division. Accumulation of naturally occurring AICAR in the body has also been linked to metabolic disorders in humans. However, AICAR has not been approved for human treatment and cannot be used as a drug. Therefore, its safety has yet to be verified.
Clinical claims and research
AICAR has proved in vivo anti-tumor effects in xenograft models. It is currently under clinical trial phase I/II to treat patients with chronic lymphocytic leukemia and has shown good safety and tolerability properties, although some side effects have been reported.
アカデシン 上流と下流の製品情報
原材料
準備製品
アカデシン 生産企業
Global( 404)Suppliers
2627-69-2(アカデシン)キーワード:
- 2627-69-2
- 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside,98%
- 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosideAICAR
- 5-Aminomidazole-4-carboxamide-1-β-D-ribofuranoside
- AICAR
- AICA-RIBOSIDE
- 1-Deoxy-1-[(4-carbamoyl-5-amino-1H-imidazole)-1-yl]-β-D-ribofuranose
- 1-β-D-Ribofuranosyl-5-amino-1H-imidazole-4-carboxamide
- 5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
- AICA-β-D-Riboside
- {[(2S,3R,4R,5R)-5-(5-aMino-4-carbaMoyl-1H-iMidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]Methoxy}phosphonic acid
- 5-AMino-4-iMidazole
carboxaMide Riboside
- Arasine
- GP 1-110
- NSC 105823
- Acadesine, AICA
- AICAR, Free Base
- N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
- AICAR,5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, Acadesine, N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
- 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranose ,98%
- Acadesine(Aicar,NSC 105823)
- 5-Amino-4-carbamoyl-1-(beta-D-ribofuranosyl)-1H-imidazole, AICAR
- Acadesine/AICAR
- AICA, Acadesine, AICA-ribaoside
- 1H-IMidazole-4-carboxaMide,5-aMino-1-b-D-ribofuranosyl-
- 5′-AMP-activated protein kinase catalytic subunit alpha-1
- AMPK1
- ANTI-AMPK ALPHA 1(C-TERMINAL) antibody produced in rabbit
- AICAR Alternate
- 5-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-imidazole-4-carboxamide
- SR9011 white powder 99%
- 4-アミノ-3-(β-D-リボフラノシル)-3H-イミダゾール-5-カルボアミド
- 1-デオキシ-1-(5-アミノ-4-カルバモイル-1H-イミダゾール-1-イル)-β-D-リボフラノース
- 5-アミノ-1-(β-D-リボフラノシル)-1H-イミダゾール-4-カルボアミド
- アカデシン
- 1-デオキシ-1-[(4-カルバモイル-5-アミノ-1H-イミダゾール)-1-イル]-β-D-リボフラノース
- AICA-リボシド
- アミノイミダゾールカルボキサミドリボフラノシド
- 5-アミノイミダゾール-4-カルボキシアミドリボヌクレオシド
- AICA-β-D-リボシド
- 5-アミノ-1-β-D-リボフラノシルイミダゾール-4-カルボキサミド
- 5-アミノ-1-β-D-リボフラノシル-1H-イミダゾール-4-カルボアミド
- 1-β-D-リボフラノシル-5-アミノ-1H-イミダゾール-4-カルボアミド
- 1-(β-D-リボフラノシル)-5-アミノ-1H-イミダゾール-4-カルボアミド
- 5-アミノイミダゾール-4-カルボキサミド-1-β-D-リボフラノシド
- アラシン
- 5-アミノイミダゾール-4-カルボキサミド1-β-D-リボフラノシド
- 5-アミノ-1-(β-D-リボフラノシル)-1H-イミダゾール-4-カルボキサミド
- 5-アミノ-1-Β-D-リボフラノシル-1H-イミダゾール-4-カルボキサミド
- AICAリボシド
- AMPK (Α2/Β2/Γ1)、活性型、HISタグ融合 ヒト
- [(2R,3S,4R,5R)-5-(4-カルバモイルイミダゾール-1-イル)-3,4-ジヒドロキシオキソラン-2-イル]メトキシホスホン酸
- 1-(5-O-ホスホノ-β-D-リボフラノシル)-1H-イミダゾール-4-カルボアミド
- {[(2R,3S,4R,5R)-5-(4-カルバモイル-1H-イミダゾール-1-イル)-3,4-ジヒドロキシオキソラン-2-イル]メトキシ}ホスホン酸