4-N-BOC-1-N-CBZ-ピペラジン-2-カルボン酸メチルエステル
4-N-BOC-1-N-CBZ-ピペラジン-2-カルボン酸メチルエステル 物理性質
- 沸点 :
- 476.9±45.0 °C(Predicted)
- 比重(密度) :
- 1.214±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 酸解離定数(Pka):
- -1.49±0.70(Predicted)
- 外観:
- 白色からオフホワイトの固体
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
4-N-BOC-1-N-CBZ-ピペラジン-2-カルボン酸メチルエステル 価格
もっと(7)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-5818 |
4-N-Boc-1-N-Cbz-ピペラジン-2-カルボン酸メチルエステル
4-N-Boc-1-n-cbz-piperazine-2-carboxylic acid methyl ester |
126937-42-6 |
1g |
￥42500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-5818 |
4-N-Boc-1-N-Cbz-ピペラジン-2-カルボン酸メチルエステル
4-N-Boc-1-n-cbz-piperazine-2-carboxylic acid methyl ester |
126937-42-6 |
5g |
￥145000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-5818 |
4-N-Boc-1-n-cbz-piperazine-2-carboxylic acid methyl ester |
126937-42-6 |
10g |
￥280000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-5818 |
4-N-Boc-1-n-cbz-piperazine-2-carboxylic acid methyl ester |
126937-42-6 |
25g |
￥590000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC303306 |
METHYL 4-N-BOC-1-N-CBZ-2-PIPERAZINE CARBOXYLATE |
126937-42-6 |
1g |
￥48100 |
2021-03-23 |
購入 |
4-N-BOC-1-N-CBZ-ピペラジン-2-カルボン酸メチルエステル 化学特性,用途語,生産方法
合成
The fully protected Methyl N-4-Boc-N-1-Cbz-2-piperazinecarboxylate was prepared from 2-piperazinecarboxylic acid as shown in the below figure. Using a sequential one-pot protection procedure similar to that used to protect lysine, a solution of 2-piperazinecarboxylic acid (24.1 g, 0.185 mol) in 1:1 dioxane-water (1.2 L) was maintained at pH 11 with 50% aqueous sodium hydroxide during the addition of a solution of 2-(t-butyloxycarbonyloxyimino)-2-phenylacetonitrile (BOC-ON, 51 g, 0.21 mol) in dioxane (0.3 L). After 3 h, the reaction mixture was cooled in an ice bath and the pH was adjusted to pH 9.5 with 6 N HCl. Benzylchloroformate was added dropwise to the cold solution while maintaining the pH with 50% aqueous sodium hydroxide. The reaction was warmed to room temperature and stirred for 24 h. The solution was washed with diethyl ether (4 x 250 mL), the aqueous layer was acidified to pH 2 and extracted with ethyl acetate (4 x 250 mL) . The organic layer was dried over magnesium sulfate, filtered and evaporated to give a pale yellow oil.
The methyl ester 5(Methyl N-4-Boc-N-1-Cbz-2-piperazinecarboxylate) was obtained by treatment of a tetrahydrofuran solution of the crude acid with excess diazomethane. Alternatively, the methyl ester could be obtained on large scale by treatment of a saturated sodium bicarbonate solution of the intermediate carboxylic acid 4 with a methylene chloride solution of methyl iodide and Adogen 464, or preferably by refluxing an acetone solution of the carboxylic acid, dimethyisulfate and potassium carbonate.
[1]
4-N-BOC-1-N-CBZ-ピペラジン-2-カルボン酸メチルエステル 上流と下流の製品情報
原材料
準備製品
4-N-BOC-1-N-CBZ-ピペラジン-2-カルボン酸メチルエステル 生産企業
Global( 50)Suppliers
4-N-BOC-1-N-CBZ-ピペラジン-2-カルボン酸メチルエステル スペクトルデータ(1HNMR)
126937-42-6(4-N-BOC-1-N-CBZ-ピペラジン-2-カルボン酸メチルエステル)キーワード:
- 126937-42-6
- 4-N-BOC-1-N-CBZ-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER
- METHYL 4-N-BOC-1-N-CBZ-2-PIPERAZINE CARBOXYLATE
- Methyl 4-Boc-1-Cbz-2-piperazinecarboxylate
- Methyl 1-(benzyloxycarbonyl)-4-(tert-butyloxycarbonyl)piperazine-2-carboxylate
- 1-(Benzyloxycarbonyl)-2-(methoxycarbonyl)-4-(tert-butoxycarbonyl)-piperazine
- (2R)-piperazine-1,2,4-tricarboxylic acid O4-tert-butyl ester O2-methyl ester O1-(phenylmethyl) ester
- 1,2,4-Piperazinetricarboxylic acid, 4-(1,1-dimethylethyl) 2-methyl 1-(phenylmethyl) ester
- Methyl (±)-1-benzyloxycarbonyl-4-Boc-piperazine-2-carboxylate
- O1-benzyl O4-tert-butyl O2-methyl piperazine-1,2,4-tricarboxylate
- Methyl N-4-Boc-N-1-Cbz-2-piperazinecarboxylate
- 4-N-BOC-1-N-CBZ-ピペラジン-2-カルボン酸メチルエステル