φ,φ-カロテン 化学特性,用途語,生産方法
外観
暗紫赤色~暗赤紫色, 結晶性粉末~粉末
定義
本品は、合成又は天然から得られるカロテノイド化合物であり、次の化学式で表される。
溶解性
クロロホルムに溶け、エタノールに極めて溶けにくく、水にほとんど溶けない。
解説
ニンジンの赤色色素.α-カロテン,β-カロテン,γ-カロテンの3種の異性体がある.いずれも分子式C
40H
56.長い鎖式構造部分に9個の共役二重結合をもつポリエン色素である.不飽和炭化水素を表す接尾語-eneを用いてカロテンと命名されているが,元来はドイツ語名Carotinをもとにしたカロチンというよび名が普及している.
用途
カロテン定量用標準品。
化粧品の成分用途
皮膚コンディショニング剤、着色剤
効能
俗称:α-カロチン (α-carotin);暗赤色 (再結 C6H6-メタノール);λmax 511, 478, 446 nm (CS2)
説明
α-Carotene is a precursor of vitamin A that has been found in various fruits and vegetables. It inhibits proliferation of GOTO human neuroblastoma cells more potently than β-carotene and halts the cell cycle at the G
0/G
1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc. It is also more potent than β-carotene in mouse models of skin and lung carcinogenesis and decreases the number of hepatomas in mice with spontaneous liver carcinogenesis when administered in drinking water at a concentration of 0.05%. α-Carotene levels are increased in patients with coronary heart disease and are inversely correlated with the risk of estrogen receptor-negative breast cancer.
使用
carotene is used to provide a red-orange color in cosmetic formulations. It is the primary yellow coloring component of butter, carrots, and egg yolk. Carotene is found in plants as well as in many animal tissues.
一般的な説明
α-Carotene is a carotenoid, which shows anticarcinogenic activity.
純化方法
Purify α-carotene by chromatography on columns of calcium hydroxide, alumina or magnesia. Crystallise it from CS2/MeOH, toluene/MeOH, diethyl ether/pet ether, or acetone/pet ether. Store it in the dark, under N2 or Ar at -20o. It gives a blue colour with max at 542nm when mixed with SbCl3 in CHCl3. [Karrer & Walker Helv Chim Acta 16 641 1933, Eugster et al. Helv Chim Acta 52 1729 1969, Eugster & Karrer Helv Chim Acta 38 610 1955, Strain J Biol Chem 105 523 1934, Beilstein 5 III 2457, 5 IV 2620.]
参考文献
von P. Karrer, O. Walker, Helv. Chim. Acta, 16, 641 (1933), DOI: 10.1002/hlca.19330160193.
φ,φ-カロテン 上流と下流の製品情報
原材料
準備製品