4-メトキシ-5-(4-ペンチル-5-メチル-2H-ピロール-2-イリデンメチル)-2,2'-ビ[1H-ピロール]

4-メトキシ-5-(4-ペンチル-5-メチル-2H-ピロール-2-イリデンメチル)-2,2'-ビ[1H-ピロール] 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

4-メトキシ-5-(4-ペンチル-5-メチル-2H-ピロール-2-イリデンメチル)-2,2'-ビ[1H-ピロール] 化学特性,用途語,生産方法

使用

Prodigiosin is an intensely red, pyrrole pigment produced by several bacteria, most notably Serratia marcescens. Prodigiosin has a broad biological profile with activity against fungi, tumour cell lines and malaria. It was shown to be an immunosuppressant in 2007. Prodigiosin acts via caspase inhibition to induce of apoptosis in human primary cancer cells. Prodigiosin also acts as an inducer of p21WAF1/CIP1 expression via transforming growth factor-β receptor pathway, and activates NAG-1 via glycogen synthase kinase-3β.

定義

ChEBI: A member of the class of tripyrroles that is a red-coloured pigment with antibiotic properties produced by Serratia marcescens.

一般的な説明

A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21^WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC₅₀ = 2.0 μM in A549-FKR cells) through inhibition of FADD-kinase CK1α (IC₅₀ ~ 6.0 μM in SW620-BGCR cells) and augments cisplatin (Cat. No. 232120)-induced apoptosis. Blocks NF-κB activation by decreasing pIκBα (by 63% at 3 μM) and IκBα levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3 mg/kg, i.p., o.d.).

酵素阻害剤

This red bacterial pigment (FWfree-base = 323.44 g/mol; melting point = 151- 152°C) is an antibiotic produced by Serratia marcescens (formerly Chromobacterium prodigiosum). Prodigiosin is the parent member of a class of pyrrole-containing natural products that exhibit immunosuppressive, cytotoxic, and apoptotic activity and can facilitate copper-promoted oxidative double-strand DNA cleavage through reductive activation of Cu2+. They also uncouple lysosomal vacuolar-type ATPases by promoting H+/Cl– symport activity. The solid pigment is dark red and displays a green reflex. Acidic aqueous solutions are also red, but neutral or alkaline solutions are orange-yellow. Target(s): DNA topoisomerase I; DNA topoisomerase II; FoF1 ATPase, or H+-transporting two-sector ATPase, as an uncoupler; H+/K+-ATPase, as an uncoupler; proton translocation, as an uncoupler; and Serratia marcescens nuclease.

4-メトキシ-5-(4-ペンチル-5-メチル-2H-ピロール-2-イリデンメチル)-2,2'-ビ[1H-ピロール] 上流と下流の製品情報

原材料

準備製品

4-メトキシ-5-(4-ペンチル-5-メチル-2H-ピロール-2-イリデンメチル)-2,2'-ビ[1H-ピロール] 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32376	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	11000	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53900	58

82-89-3(4-メトキシ-5-(4-ペンチル-5-メチル-2H-ピロール-2-イリデンメチル)-2,2'-ビ[1H-ピロール])キーワード:

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• 82-89-3
• PRODIGIOSIN
• (Z)-4-Methoxy-5-((5-Methyl-4-pentyl-2H-pyrrol-2-ylidene)Methyl)-1H,1'H-2,2'-bipyrrole
• 3-Methoxy-2-(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl-5-(1H-pyrrol-2-yl)-1H-pyrrole
• 4-Methoxy-5-(4-pentyl-5-methyl-2H-pyrrole-2-ylidenemethyl)-2,2'-bi[1H-pyrrole]
• 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi[1H-pyrrol]
• 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi[1H-pyrrole]
• Prodigiosine
• 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl], 2,2'bipyrrole
• Aids010622
• Aids-010622
• Nsc47147
• 2,2'-Bi-1H-pyrrole,4-Methoxy-5-[(5-Methyl-4-pentyl-2H-pyrrol-2-ylidene)Methyl]-prodigiosinⅡ≤
• 2,2'-Bi-1H-pyrrole,4-Methoxy-5-[(5-Methyl-4-pentyl-2H-pyrrol-2-ylidene)Methyl]-
• 2-Methyl-3-amyl-6-methoxyprodigiosene
• (E)-4-methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)-1H,1'H-2,2'-bipyrrole
• Prodigiosin, apoptotic agent
• Prodigiosin Serratia marcescens
• 4-Methoxy-5-((5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl)-1H,1'H-2,2'-bipyrrole
• 3-メトキシ-2-(5-メチル-4-ペンチル-2H-ピロール-2-イリデン)メチル-5-(1H-ピロール-2-イル)-1H-ピロール
• 4-メトキシ-5-(4-ペンチル-5-メチル-2H-ピロール-2-イリデンメチル)-2,2'-ビ[1H-ピロール]
• プロジギオシン
• 4-メトキシ-5-[(5-メチル-4-ペンチル-2H-ピロール-2-イリデン)メチル]-2,2'-ビ[1H-ピロール]
• 4-メトキシ-5-[(5-メチル-4-ペンチル-2H-ピロール-2-イリデン)メチル]-1H,1'H-2,2'-ビピロール
• 4-メトキシ-5-[(5-メチル-4-ペンチル-2H-ピロール-2-イリデン)メチル]-2,2′-ビ[1H-ピロール]
• 4-メトキシ-5-(4-ペンチル-5-メチル-2H-ピロール-2-イリデンメチル)-2,2′-ビ[1H-ピロール]
• 4-メトキシ-5-(4-ペンチル-5-メチル-2H-ピロール-2-イリデンメチル)-2,2′-ビ(1H-ピロール)
• 抗生物質
• 抗真菌薬