PRODIGIOSIN
- CAS No.
- 82-89-3
- Chemical Name:
- PRODIGIOSIN
- Synonyms
- Nsc47147;Aids010622;Aids-010622;PRODIGIOSIN;Prodigiosine;Prodigiosin, apoptotic agent;2-Methyl-3-amyl-6-methoxyprodigiosene;Prodigiosin Serratia marcescens;4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl], 2,2'bipyrrole;4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2'-bi[1H-pyrrol]
- CBNumber:
- CB5156304
- Molecular Formula:
- C20H25N3O
- Molecular Weight:
- 323.43
- MDL Number:
- MFCD01740630
- MOL File:
- 82-89-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 151-152° |
|---|---|
| Boiling point | 554.3±50.0 °C(Predicted) |
| Density | 1.12±0.1 g/cm3(Predicted) |
| storage temp. | -20C |
| solubility | Acetonitrile: Soluble; Ethanol: Soluble; Methanol: Soluble |
| form | Dark red solid |
| pka | 17.09±0.50(Predicted) |
| color | Dark red |
| InChI | InChI=1S/C20H25N3O/c1-4-5-6-8-15-11-16(22-14(15)2)12-19-20(24-3)13-18(23-19)17-9-7-10-21-17/h7,9-13,21,23H,4-6,8H2,1-3H3 |
| InChIKey | SZXDNGVQRDTJSD-UHFFFAOYSA-N |
| SMILES | N1C(C=C2C=C(CCCCC)C(C)=N2)=C(OC)C=C1C1=CC=CN1 |
| FDA UNII | OL369FU7CJ |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
PRODIGIOSIN price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 529685 | Prodigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem Acell-permeabletripyrrolealkaloidcompoundthatdisplaysimmunosuppressivean | 82-89-3 | 200μg | $205 | 2026-04-30 | Buy |
| Cayman Chemical | 19464 | Prodigiosin ≥95% | 82-89-3 | 250μg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 19464 | Prodigiosin ≥95% | 82-89-3 | 500μg | $168 | 2026-04-30 | Buy |
| Cayman Chemical | 19464 | Prodigiosin ≥95% | 82-89-3 | 1mg | $280 | 2026-04-30 | Buy |
| Usbiological | P9005-85 | Prodigiosin ~95% | 82-89-3 | 500ug | $523 | 2026-06-04 | Buy |
PRODIGIOSIN Chemical Properties, Uses, Production
Uses
Prodigiosin is an intensely red, pyrrole pigment produced by several bacteria, most notably Serratia marcescens. Prodigiosin has a broad biological profile with activity against fungi, tumour cell lines and malaria. It was shown to be an immunosuppressant in 2007. Prodigiosin acts via caspase inhibition to induce of apoptosis in human primary cancer cells. Prodigiosin also acts as an inducer of p21WAF1/CIP1 expression via transforming growth factor-β receptor pathway, and activates NAG-1 via glycogen synthase kinase-3β.
Uses
Prodigiosin is an intensely red pyrrole pigment produced by several bacteria, most notably Serratia marcescens. Prodigiosin has a broad biological profile with activity against fungi, tumor cell lines and malaria. It was shown to be an immunosuppressant in 2007. Prodigiosin acts via caspase inhibition to induce of apoptosis in human primary cancer cells. Prodigiosin also acts as an inducer of p21WAF1/CIP1 expression via transforming growth factor-β receptor pathway, and activates NAG-1 via glycogen synthase kinase-3β.
Uses
Prodigiosin is a naturally occurring pigment which occurs as a product of Serratia marcescens. Pink colored pigment.
Definition
ChEBI: A member of the class of tripyrroles that is a red-coloured pigment with antibiotic properties produced by Serratia marcescens.
General Description
A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50 = 2.0 μM in A549-FKR cells) through inhibition of FADD-kinase CK1α (IC50 ~ 6.0 μM in SW620-BGCR cells) and augments cisplatin (Cat. No. 232120)-induced apoptosis. Blocks NF-κB activation by decreasing pIκBα (by 63% at 3 μM) and IκBα levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3 mg/kg, i.p., o.d.).
Enzyme inhibitor
This red bacterial pigment (FWfree-base = 323.44 g/mol; melting point = 151- 152°C) is an antibiotic produced by Serratia marcescens (formerly Chromobacterium prodigiosum). Prodigiosin is the parent member of a class of pyrrole-containing natural products that exhibit immunosuppressive, cytotoxic, and apoptotic activity and can facilitate copper-promoted oxidative double-strand DNA cleavage through reductive activation of Cu2+. They also uncouple lysosomal vacuolar-type ATPases by promoting H+/Cl– symport activity. The solid pigment is dark red and displays a green reflex. Acidic aqueous solutions are also red, but neutral or alkaline solutions are orange-yellow. Target(s): DNA topoisomerase I; DNA topoisomerase II; FoF1 ATPase, or H+-transporting two-sector ATPase, as an uncoupler; H+/K+-ATPase, as an uncoupler; proton translocation, as an uncoupler; and Serratia marcescens nuclease.
storage
+4°C
PRODIGIOSIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Hi-Future Biotechnology Co., Ltd | +86-0513; 18051384581 | sales@chemhifuture.com | China | 3075 | 58 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
View Latest Price from PRODIGIOSIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-30 | Prodigiosin
82-89-3
|
$197.00 | 99.99% | 10g | TargetMol Chemicals Inc. |
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- Prodigiosin
82-89-3
- $197.00
- 99.99%
- TargetMol Chemicals Inc.
