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RS 102895 塩酸塩

RS 102895 塩酸塩 化学構造式
300815-41-2
CAS番号.
300815-41-2
化学名:
RS 102895 塩酸塩
别名:
RS 102895 塩酸塩
英語名:
RS 102895
英語别名:
RS 102895 HYDROCHLORIDE;1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;RS102895, 10 mM in DMSO;CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-;1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE
CBNumber:
CB6504368
化学式:
C21H21F3N2O2
分子量:
390.4
MOL File:
300815-41-2.mol

RS 102895 塩酸塩 物理性質

沸点 :
446.1±45.0 °C(Predicted)
比重(密度) :
1.33±0.1 g/cm3 (20 ºC 760 Torr)
貯蔵温度 :
Desiccate at RT
溶解性:
DMSO：18 mg/mL 無色透明
外見 :
粉
酸解離定数(Pka):
13.46±0.20(Predicted)
色:
白い
InChI:
1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
InChIKey:
KRRISOFSWVKYBF-UHFFFAOYSA-N
SMILES:
Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1

安全性情報

Sフレーズ  22-24/25
WGK Germany  3
ストレージクラス 11 - Combustible Solids

RS 102895 塩酸塩 価格 もっと(1)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan R1903 RS 102895 塩酸塩 ≥98% (HPLC), powder
RS 102895 hydrochloride ≥98% (HPLC), powder		 300815-41-2 5mg ￥35700 2024-03-01 購入

RS 102895 塩酸塩 化学特性,用途語,生産方法

使用

RS 102895 is a CCR2-selective chemokine receptor inhibitor.

生物活性

CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.

RS 102895 塩酸塩 上流と下流の製品情報

原材料

準備製品

RS 102895 塩酸塩 生産企業

Global( 114)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Shanghai Boyle Chemical Co., Ltd.
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LETOPHARM LIMITED +86-21-5821 5861
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EMMX Biotechnology LLC 888-539-0666
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Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 9780 55

RS 102895 塩酸塩  スペクトルデータ(1HNMR)

RS 102895(300815-41-2)1HNMR

300815-41-2(RS 102895 塩酸塩)キーワード:

2,3-ジクロロ-5-(トリフルオロメチル)ピリジン スピロ[4H-3,1-ベンゾキサジン-4,4'-ピペリジン]-2(1H)-オン RS 102895 塩酸塩
  • 300815-41-2
  • 1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride
  • 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride
  • 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one
  • 1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE
  • Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-
  • 1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
  • CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895
  • RS102895, 10 mM in DMSO
  • RS 102895 HYDROCHLORIDE
  • RS 102895 塩酸塩
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