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RS 102895

RS 102895 Structure
RS 102895 structure
CAS No.
300815-41-2
Chemical Name:
RS 102895
Synonyms
RS 102895 HYDROCHLORIDE;1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;RS102895, 10 mM in DMSO;CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one;Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-;1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride;1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride;1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE
CBNumber:
CB6504368
Molecular Formula:
C21H21F3N2O2
Molecular Weight:
390.4
MDL Number:
MFCD05865241
MOL File:
300815-41-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-10 08:17:50
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RS 102895 Properties

Boiling point 446.1±45.0 °C(Predicted)
Density 1.33±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. Desiccate at RT
solubility DMSO: 18 mg/mL, clear, colorless
form powder
pka 13.46±0.20(Predicted)
color white
InChI 1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
InChIKey KRRISOFSWVKYBF-UHFFFAOYSA-N
SMILES Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1
UNSPSC Code 12352202
NACRES NA.32

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
Storage Class 11 - Combustible Solids

RS 102895 price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich R1903 RS 102895 hydrochloride ≥98% (HPLC), powder 300815-41-2 5mg $264 2026-04-30 Buy
TCI Chemical R0267 RS-102895 300815-41-2 5MG $107 2026-04-30 Buy
Usbiological 217756 RS 102895 Hydrochloride (1’-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4’-piperidin]-2(1H)-one Hydrochloride, RS 102895, RS102895) ≥98%(HPLC) 300815-41-2 5mg $438 2026-06-03 Buy
Biosynth FR102476 RS 102895 300815-41-2 5mg $250 2026-06-04 Buy
Biosynth FR102476 RS 102895 300815-41-2 10mg $331.3 2026-06-04 Buy
Product number Packaging Price Buy
R1903 5mg $264 Buy
R0267 5MG $107 Buy
217756 5mg $438 Buy
FR102476 5mg $250 Buy
FR102476 10mg $331.3 Buy

RS 102895 Chemical Properties, Uses, Production

Uses

RS 102895 is a CCR2-selective chemokine receptor inhibitor.

Biological Activity

CCR2-selective chemokine receptor antagonist (IC 50 values are 0.36 and 17.8 μ M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC 50 values of 32 nM and 1.7 μ M respectively. Also inhibits α 1A , α 1D and 5-HT 1A receptors.

in vivo

RS102895 (3 g/L) causes progressive decrease in pain threshold in rats with bone cancer pain (BCP) at day 3-9 after surgery via intrathecal injection, but the pain threshold increases after 12 days. RS102895 also potently reverses the pattern of NR2B, nNOS, and SIGIRR expression in spinal cord[3].

IC 50

CCR2: 360 nM (IC50); CCR1: 17800 nM (IC50); Human α1a receptor: 130 nM (IC50); Human α1d receptor: 320 nM (IC50); 5HT-1a receptor: 470 nM (IC50)

RS 102895 Preparation Products And Raw materials

Raw materials

Preparation Products

RS 102895 Suppliers

Global Suppliers ( 114)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10244 55
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2374 58
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9782 55
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
3B Pharmachem (Wuhan) International Co.,Ltd. 69
VDM Biochemicals 64
MedChemexpress LLC 58
Quality Control Solutions Ltd. 56
Shanghai YuLue Chemical Co., Ltd. 55
LETOPHARM LIMITED 58
EMMX Biotechnology LLC 60
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55

View Latest Price from RS 102895 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RS102895 pictures 2026-09-10 RS102895
300815-41-2
 $59.00-178.00 99.80% 10g TargetMol Chemicals Inc.
RS 102895 pictures 2026-07-02 RS 102895
300815-41-2
 1KG 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
RS 102895 pictures 2025-04-04 RS 102895
300815-41-2
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
  • RS102895 pictures
  • RS102895
    300815-41-2
  • $59.00-178.00
  • 99.80%
  • TargetMol Chemicals Inc.
  • RS 102895 pictures
  • RS 102895
    300815-41-2
  • $0.00
  • 98%
  • Shaanxi Dideu New Materials Co. Ltd
  • RS 102895 pictures
  • RS 102895
    300815-41-2
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.

RS 102895 Spectrum

RS 102895(300815-41-2)1HNMR

300815-41-2 (RS 102895) Related Search:

2,3-Dichloro-5-(trifluoromethyl)pyridine 2-fluoro-6-(trifluoroMethyl)benzene-1-sulfonyl chloride Inter-trifluoromethyl iodobenzene 4-(O-Amino-phenyl) piperidine hydrochloride Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
4-(2-Aminophenyl)-1-phenethylpiperidine RS 102895 1-Phenethyl-4-phenyl-4-piperidinol

1of2

1'-(4-(TrifluoroMethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one,hydrochloride 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4h-3,1-benzoxazine-4,4'-peperidin]-2(1h)-one 1'-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE HYDROCHLORIDE Spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]- 1'-(4-(trifluoromethyl)phenethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one CC chemokine receptor,CCR,Inhibitor,RS102895,inhibit,RS-102895,RS 102895 RS102895, 10 mM in DMSO RS 102895 HYDROCHLORIDE 300815-41-2 C21H21F3N2O2HCl RS 102895 CCR2-selective chemokine receptor antagonist. Cytokine signaling