6-アミノ-3-メチル-3H-プリン 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
説明
Autophagy is a multi-
step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms. mTOR, whose activation is controlled by phosphoinositide 3-
kinase (PI3K), is a key regulator of autophagy. 3-
Methyladenine (3-
MA) is a specific inhibitor of PI3K activity and one of the most widely used inhibitors of the initial phase of the autophagic process: the sequestering of cytoplasmic material by the lysosome. At 5 mM, 3-
MA inhibits protein degradation in rat hepatocytes by 65%. 3-
MA has been shown to block class I, class II, and class III PI3Ks, including some downstream targets, and to suppress the invasion of highly metastatic human fibrosarcoma HT1080 cells at 10 mM.
化学的特性
White powder
使用
3-Methyladenine (3-MA) inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.
定義
ChEBI: A methyladenine that is adenine substituted with a methyl group at position N-3.
一般的な説明
A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC
50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos.
440202 and
440204) and Wortmannin (Cat. No.
681675)
6-アミノ-3-メチル-3H-プリン 上流と下流の製品情報
原材料
準備製品