포르볼
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포르볼 속성
- 녹는점
- 162-163° and 233-234°; mp 249-250°
- 알파
- D24 +102° (water); D20 +118° (c = 0.4 in dioxane)
- 끓는 점
- 415.62°C (rough estimate)
- 밀도
- 1.4
- 굴절률
- 1.4450 (estimate)
- 저장 조건
- Sealed in dry,Store in freezer, under -20°C
- 수용성
- 물에 용해됨
- 용해도
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: slightly soluble; PBS (pH 7.2): 1 mg/ml
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 11.36±0.70(Predicted)
- 색상
- White to Orange to Green
- InChIKey
- QGVLYPPODPLXMB-UBTYZVCOSA-N
- SMILES
- C1(=O)[C@]2(O)[C@]([H])([C@@]3(O)[C@H](C)[C@@H](O)[C@@]4(O)C(C)(C)[C@@]4([H])[C@]3([H])C=C(CO)C2)C=C1C
- CAS 데이터베이스
- 17673-25-5
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T+ | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 26/27/28-36/37/38 | ||
| 안전지침서 | 26-27-36/37/39-45-28 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | GZ0600000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29062990 | ||
| 유해 물질 데이터 | 17673-25-5(Hazardous Substances Data) |
포르볼 C화학적 특성, 용도, 생산
개요
Phorbol is a diterpene originally isolated from croton oil. It is used as a starting material for the semisynthesis of various phorbol diesters, which are structurally analogous to diacylglycerol and activate PKC isoforms by associating with their C1 domains.용도
Phorbol is a plant-derived diterpene that exhibits various biological activities such as its role as tumor promoters through the activation of protein kinase C.정의
ChEBI: A diterpenoid with the structure of tigliane hydroxylated at C-4, -9, -12(beta), -13 and -20, with an oxo group at C-3 and unsaturation at the 1- and 6-positions.제조 방법
Phorbol can be extracted from croton oil by two-phase alcoholysis and purified by high-speed counter-current chromatography[1]. The specific method is as follows:The optimized operation conditions of biphasic alcoholysis were a reaction time of 91 min, a temperature of 14°C, and a croton oil-methanol ratio of 1:30 (g:ml). The phorbol during the biphasic alcoholysis was 3.2-fold higher in content than that obtained in conventional monophasic alcoholysis. The optimized high-speed countercurrent chromatography method was using the ethyl acetate/n-butyl alcohol/water at 4.7:0.3:5 (v:v:v) with Na2SO4 at 0.36 g/10 ml as the solvent system, using the mobile phase flow rate of 2 ml/min, the revolution of 800 r/min, under which the retention of the stationary phase was achieved at 72.83%. The crystallized phorbol following high-speed countercurrent chromatography was obtained as high purity of 94%.
일반 설명
White solid.공기와 물의 반응
Water soluble.반응 프로필
PHORBOL is unstable to prolonged exposure to air, light and ambient temperatures. PHORBOL is also sensitive to acid and alkalis and is subject to autooxidation. PHORBOL dissolves slowly, therefore solution in a desired solvent is best accomplished by prolonged shaking under an inert atmosphere. .화재위험
PHORBOL is probably combustible.포르볼 준비 용품 및 원자재
원자재
준비 용품
포르볼 공급 업체
글로벌( 116)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 |
sales@biopurify.com | China | 3772 | 58 |
| Hpets Biotech Company (Chongqing) Co.,ltd | +8613340353813 |
info@hanpets.com | China | 26 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29856 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 |
sale02@cqherb.com | CHINA | 376 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32268 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23541 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9304 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10473 | 58 |
포르볼 관련 검색:
포르볼 PHORBOL12,13-디아세테이트 포르볼12,13-디부티레이트 포르볼12,13-디데카노에이트 포르볼12-미리스테이트13-아세테이트4-O-메틸에테르,4베타 포르볼12-N-메틸란트라닐레이트 12-디옥시포르볼13-이소부티레이트20-아세테이트 포르볼13-미리스테이트 포르볼13-아세테이트 포르볼-12-데카노에이트 포르볼12,13,20-트리아세테이트,4베타 포르볼-12-모노미리스테이트 포르볼16-하이드록시12-팔미테이트13-아세테이트 20-OXO-20-DEOXYPHORBOL12,13-디부티레이트 포르볼12-모노아세트산,4베타 PHORBOL13,20-디아세테이트 포르볼-12-TIGLIATE-13-데카노에이트 포르볼12,13-디벤조에이트