45%(w/v) aq 2-하이드록시프로필-β-사이클로덱스트린: 0.2mg/mL 용액은 4℃에서 며칠 동안 보관할 수 있습니다.
산도 계수 (pKa)
12.93±0.70(Predicted)
물리적 상태
가루
색상
하얀색
수용성
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2mg/mL (Solutions may be stored for several days at 4 °C.) DMSO: 14mg/mL (Solutions may be stored for several days at 4 °C.) 0.1 M HCl: 3.4mg/mL (Solutions may be stored for several days at 4 °C.) H2O: insoluble ethanol: soluble (Solutions may be stored for several days at 4 °C.)
A potent adenosine receptor agonist. Inhibits platelet aggregation and is centrally active in vivo
정의
ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.
일반 설명
A cell-permeable adenosine analog that acts a potent non-selective agonist of adenosine receptors (Ki = 14 nM, 20 nM, 2.4 μM and 6.2 nM for A1, A2A, A2B, A3, respectively). Increases intracellular cAMP production (EC50 = 3.1 μM in A2B expressing CHO cells). Shown to increase glucagon release in a dose-dependent manner and inhibit insulin release at low concentrations. Although at higher concentration some insulin release is observed. Also, displays a wide range adenosine-dependent effects, such as blocking platelet aggregation and inhibiting DNA synthesis. When administered at reperfusion, it is shown reduce infarction and block the formation of the mitochondrial permeability transition pore by activating p70S6 kinase.
생물학적 활성
Potent adenosine receptor agonist (K i values are 14, 20 and 6.2 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .
