PAI-1

PAI-1 C화학적 특성, 용도, 생산

효소 저해제

This 402-residue serine protease inhibitor, or serpin (MW = 45074 g/mol; Abbreviation: PAI-1) binds to and inhibits plasminogen activators-tissuetype plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). This inhibition reduces plasmin production and suppresses dissolution of fibrin clots. Elevated PAI-1 levels correlate with an increased cardiovascular disease risk, a behavior that has also been linked to obesity and metabolic syndrome. Pharmacological suppression of PAI-1 is a likely way to prevent or treat vascular disease. Reduced PAI-1 levels may result in increased fibrinolysis and an associated bleeding diathesis. PAI-1 was initially identified in the 1980s, and the first reported case of PAI-1 deficiency appeared in 1989. Unambiguous proof that PAI-1 deficiency as a cause of a bleeding disorder has been rare, but use of selective PAI inhibitors (See PAI-749) may clarify this point. Because of lack of standardized commercially available PAI-1 activity assay sensitive in the lowest range, the true prevalence of this rare condition has yet to be established.

PAI-1 준비 용품 및 원자재

원자재

준비 용품

PAI-1 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai Yaji Biological Technology Co., Ltd.	021-34661275 15301693058	yajikit@163.com	China	9890	58
Shanghai Huzhen Industrial Co., LTD	021-60345367 13916550749	sales@shzbio.com	China	9965	58
Bio Rad Laboratories Inc	65-64153170	Sales.China@bio-rad.com	China	6054	58
BioVendor R D	420-549124185	info@biovendor.com	China	1266	58
Enzo Biochem Inc	Enzo Biochem Inc. 13797054060	Enzoname@qq.com	China	6174	58
Merck KGaA	21-20338288	ordercn@merckgroup.com	China	6394	58
Signalway Antibody LLC	025-58868422	info@sabbiotech.com	China	6243	58
Wanlei Life Sciences (Shenyang) Co Ltd	400-6020407	sales@wanleibio.com	China	1216	58
Beijing Biosynthesis Biotechnology Co Ltd	400-9019800	sales@bioss.com.cn	China	6102	58
Cohesion Biosciences	0512-67583809	sales@cohesionbio.com	China	6282	58