MI-503
|
|
MI-503 속성
- 끓는 점
- 782.9±60.0 °C(Predicted)
- 밀도
- 1.48±0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO : 50 mg/mL (88.55 mM);Water : < 0.1 mg/mL (insoluble)
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 14.10±0.50(Predicted)
- 색상
- White to off-white
- InChIKey
- DETOMBLLEOZTMZ-UHFFFAOYSA-N
- SMILES
- N1(CC2=CNN=C2)C2=C(C(C)=C(CN3CCC(NC4N=CN=C5SC(CC(F)(F)F)=CC5=4)CC3)C=C2)C=C1C#N
안전
MI-503 C화학적 특성, 용도, 생산
용도
MI-503 is used in the pharmacological inhibition of menin-MLL interaction that blocks progression of MLL leukemia in vivo.Biochem/physiol Actions
MI-503 is a highly potent menin-MLL interaction inhibitor (cell-free IC50 = 14.7 nM against 1 nM FITC-MLL(4-13) peptide; cellular IC50 = 220 nM using HEK293 MLL-AF9 fusion transfectants) that targets menin MLL-binding site with high affinity (KD = 9.3 nM by ITC). MI-503 selectively inhibits mixed lineage leukemia (MLL) oncogenic fusion-driven cancer progression in cultures (GI50 from 250 to 570 nM; GI50 >5 μM against cells without MLL gene translocation) and is efficacious against human MLL leukemia MV4; tumor growth in mice in vivo (by 80-100%; 60 mg/kg/day i.p.) with good pharmacokinetic properties, oral bioavailability (73% post 30 mg/kg p.o.), and no adverse effects to the animals.MI-503 준비 용품 및 원자재
원자재
준비 용품
MI-503 공급 업체
글로벌( 101)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hubei Chuchang Biotech Co., Ltd. | +undefined15623860702 |
info@chuchangbiotech.com | China | 202 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 |
sales@sarms4muscle.com | China | 10473 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 |
sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; |
support@targetmol.com | United States | 39035 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +852-852-95427495 +85295427495 |
kathy@hbyinsheng.com | China | 3512 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8467 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 |
nickzhang@hangyubiotech.com | China | 10996 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 |
sales@bicbiotech.com | China | 5994 | 58 |