오를리스타트 C화학적 특성, 용도, 생산
개요
Orlistat의 작용은 일반적으로 음식에서 지방의 흡수를 막음으로써 섭취하는 칼로리의 양을 줄이는 것을 의미합니다. 다른 많은 체중 감량 약물과 마찬가지로, 오를리 스타트 운동 및식이 요법과 같은 다른 생활 습관 개선과 함께 사용하기위한 것입니다. 임상 연구에 따르면이 복합제를 사용하는 사람들은 체중 감량 연대에 약물을 포함하지 않는 것보다 2-3 킬로그램 더 잃을 수 있습니다.
용도
Orlistat에 대한 바람직한 측면 중 하나는 체중 감량에 도움이 될뿐만 아니라 혈압도 합리적으로 낮추는 데 도움이된다는 것입니다. 또한이 체중 관리 약물은 라이프 스타일 변화와 동일한 방식으로 비만인 사람들에게 2 형 당뇨병의 발병을 예방한다고 알려져 있습니다.
개요
Orlistat was launched in the UK as Xenical for the long-term treatment
of obesity, preferably in conjunction with a moderately reduced calorie diet.
Orlistat is a tetrahydro-derivative of the natural hypolipaemic lipstatin (from
Streptomyces toxyfncini) and can be obtained either by hydrogenation of
lipstatine or by several different synthetic ways involving many steps from ( S ) -
rnalic acid. Orlistat is a potent inhibitor of gastrointestinal lipases required for the
lipolysis and digestion of dietary fat, in particular of pancreatic lipase ; as a
result, it prevents the absorption of about one third of the fat contained in food
and acts as an effective weight-reducing therapy. The outcomes of several
clinical trials involving thousands of obese patients showed that Orlistat
promotes a significant weight loss (often between 5 and 10% after one year) and
improves cardiovascular risk factors such as total cholesterol, LDL/HDL ratio,
blood glucose levels, insulin, blood pressure. Orlistat has minimal systemic
absorption, the majority of the compound itself being recovered in the feces ; it
does not affect other gastrointestinal processes, or the absorption of other
rnacronutrients such as carbohydrates and proteins.
화학적 성질
Off-White Solid
용도
Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.
일반 설명
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Orlistat is a specific lipase inhibitor derived from lipostatin, which is naturally produced by
Streptomyces toxytricini. Lipase inhibition induced by orlistat reduces the absorption of dietary fat, thereby contributing to caloric deficit.
생물학적 활성
Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A 2 , liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G 1 /S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo .
오를리스타트 준비 용품 및 원자재
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