4-(4-Aminophenoxy)-N-methylpicolinamide
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4-(4-Aminophenoxy)-N-methylpicolinamide 속성
- 녹는점
- 110-112°C
- 끓는 점
- 476.8±40.0 °C(Predicted)
- 밀도
- 1.241±0.06 g/cm3(Predicted)
- 증기압
- 0.001-0.05Pa at 20-109.84℃
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- solid
- 산도 계수 (pKa)
- 13.96±0.46(Predicted)
- 색상
- White to Light yellow to Light orange
- InChI
- InChI=1S/C13H13N3O2/c1-15-13(17)12-8-11(6-7-16-12)18-10-4-2-9(14)3-5-10/h2-8H,14H2,1H3,(H,15,17)
- InChIKey
- RXZZBPYPZLAEFC-UHFFFAOYSA-N
- SMILES
- C1(C(NC)=O)=NC=CC(OC2=CC=C(N)C=C2)=C1
- LogP
- 0.9 at 25℃ and pH7
- 표면장력
- 71.71mN/m at 883.8mg/L and 20.1℃
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험 등급 | IRRITANT | ||
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| HS 번호 | 2933399990 |
| 그림문자(GHS): |
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| 신호 어: | Warning | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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4-(4-Aminophenoxy)-N-methylpicolinamide C화학적 특성, 용도, 생산
화학적 성질
Light-Brown Solid용도
Sorafenib intermediateSynthesis
To a solution of 4-aminophenol (1 g, 9.2 mmol) in DMF (20 mL) was added 1M potassium ier/-butoxide in THF (9.7 mL, 9.7 mmol) at room temperature. After 2h, (4-chloro(2-pyridyl))-N- methyl carboxamide (1.6 g, 9.2 mmol) and potassium carbonate (0.64 g, 4.6 mmol) were added, and then the reaction mixture was heated to 80 °C for 6h. After cooling, the reaction mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with brine (20 mL) and dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography to afford 4-(4-Aminophenoxy)-N-methylpicolinamide (2.2 g, 80 %) as a light-brown solid.4-(4-Aminophenoxy)-N-methylpicolinamide 준비 용품 및 원자재
원자재
p-니트로페놀
4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
4-CHLORO-N,N-DIMETHYL-PYRIDINE-2-CARBOXAMIDE
Sorafenib Impurity 35
4-아미노페놀
4-Chloro-N-methylpicolinamide
메틸알콜
수소
팔라듐
활성화 챠콜
준비 용품
4-(4-Aminophenoxy)-N-methylpicolinamide 공급 업체
글로벌( 426)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Alfa Chemical Co., Ltd | +8615838112936 |
alfa10@alfachem.cn | China | 12931 | 58 |
| Shandong Jihui Chemical Co., Ltd. | +8615053042019 |
sales@jihuichem.com | China | 34 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20176 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 |
sales@capot.com | China | 29734 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21620 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |