Anti-UNC18;Anti-HUNC18;ANTI-STXBP1;ANTI-RB-SEC-1;ANTI-MUNC-18-1;ANTI-MUNC-18ALPHA;ANTI-SYNTAXIN-BINDING PROTEIN 1;Anti-Munc-18-1 antibody produced in rabbit;Monoclonal Anti-STXBP1 antibody produced in mouse;Anti-MUNC18/STXBP1 (Isoform A) antibody produced in goat
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
ANTI-MUNC-18-1 C화학적 특성, 용도, 생산
용도
Anti-Munc-18-1 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
일반 설명
Munc-18-1 (67 kDa) is an abundant neuronal protein that tightly binds to the synaptic fusion protein syntaxin. It is primarily expressed in neuronal tissues. Both Munc-18-1 and 2 isoforms bind tightly to syntaxins 1A, 2, and 3.
Biochem/physiol Actions
Munc-18-1 functions in synaptic vesicle exocytosis. It modulates neurotransmission by associating with syntaxin 1. Munc-18-1 binds to both syntaxin 1A and 1B isoforms, inhibiting the binding of t-soluble N-ethylmaleimide-sensitive factor-attached protein receptor (SNARE) synaptobrevin/vesicle-associated membrane protein (VAMP) and SNAP25 to syntaxin 1 and preventing SNARE assembly. Munc-18 is required for neurotransmitter secretion from synaptic vesicles throughout development and has been implicated in axonal branching in hippocampal neurons.
