소듐하이알루로네이트
|
|
소듐하이알루로네이트 속성
- 녹는점
- >209°C (dec.)
- 알파
- D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951)
- 저장 조건
- -20°C
- 용해도
- H2O: 5 mg/mL, 투명, 무색
- 물리적 상태
- 가루
- 색상
- 흰색에서 크림색으로
- 수소이온지수(pH)
- pH(2g/l,25℃) : 5.5～7.5
- 생물학적 소스
- chicken (rooster comb)
- 수용성
- 녹는
- Merck
- 13,4776
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- InChIKey
- MAKUBRYLFHZREJ-JWBQXVCJSA-M
- SMILES
- [C@@H]1(O[C@H]2[C@H](O)[C@H]([C@H](O)O[C@@H]2C(=O)[O-])O)O[C@H](CO)[C@@H](O)C[C@H]1NC(=O)C.[Na+] |&1:0,2,3,5,6,9,15,18,21,r|
- LogP
- -6.623 (est)
- CAS 데이터베이스
- 9067-32-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | B,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 22-24/25-36/37/39-27-26 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | MT7250000 | ||
| F 고인화성물질 | 3-10 | ||
| HS 번호 | 39139000 | ||
| 독성 | LD50 oral in rabbit: > 1gm/kg |
소듐하이알루로네이트 C화학적 특성, 용도, 생산
개요
닭벼슬에서 추출되는 성분으로 히알루론산의 소듐염 뮤코 다당류의 일종6000배의 수분 함유량을 가지고 수분 향상성을 유지하는 생체폴리머임천연 보습 성분 중 하나인 소듐하이알루로네이트는 히알루론산으로 많이 불려짐.효과
표피의 탈락을 방지하고 모공을 축소하는 효과를 부여하여 표피의 위축을 방지하고 보습성분을 유지시키는데 도움을 줍니다.천연보습인자의 한 종류로 피부 장벽을 강화시키는데 도움을 줍니다.
제품 소개
분자량에 따라 저분자, 고분자, 중분자의 형태로 원료가 공급됨 분자량(10 ~ 150 kDa)의 소듐하이알루로네이트는 콜라겐과 체내 히알루론산의 합성을 촉집합니다. 피부 깊숙히 침투해 피부재생, 턴오버를 촉진하여 피부 결합을 강화하고 탄력을 증진시키며, 자외선으로인한 피부 손상을 빠른 시간안에 회복 시켜줍니다. 분자량(0.15 ~ 1.3MDa)의 소듐하이알루로네이트는 각질층의 장벽기능을 안정화시키고 세포간 커뮤니케이션을 촉진하며 피부의 염증 발생을 조절합니다. 피부수화 효과로 촉촉한 피부를 만들어줍니다.화학적 성질
The PhEur 6.3 describes sodium hyaluronate as the sodium salt of hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. Sodium hyaluronate occurs as white to off-white powder or granules. It is very hygroscopic.용도
sodium hyaluronate is used as a humectant to increase moisture in the skin, it may also serve as an emulsifier. Sodium hyaluronate is capable of binding 1,800 times its own weight in water. It is the sodium salt of hyaluronic acid and is the most commonly used form.정의
Sodium Hyaluronate is a polysaccharide of linear and repeating structural units of the disaccharide D-glucuronic acid and N-acetylD-glucosamine. Hyaluronic acid in human body usually present as polymers with several million molecular weight, and the structural difference by the animal species has not been confirmed.생산 방법
Sodium hyaluronate occurs naturally in vitreous humor, serum, chicken combs, shark skin, and whale cartilage; it is usually extracted and purified from chicken combs. It may also be manufactured by fermentation of selected Streptococcus zooepidemicus bacterial strains; sodium hyaluronate is removed from the fermentation medium by filtration and purified by ultrafiltration. It is then precipitated with an organic solvent and dried.주요 응용
Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Sodium hyaluronate is widely used as follows:antifungal agent.
prevents thromboembolic complications.
aldosterone antagonist used as an adjunct in the management of chronic heart failure.
suitable as substrate for hyaluronidase.
Surgical aid (ophthalmological).
Pharmaceutical Applications
Sodium hyaluronate is the predominant form of hyaluronic acid at physiological pH. The name hyaluronan is used when the polysaccharide is mentioned in general terms, and in the literature the terms hyaluronic acid and sodium hyaluronate are used interchangeably.Hyaluronan is used therapeutically to treat osteoarthritis in the knee, and is an effective treatment for arthritic pain. Crosslinked hyaluronan gels are used as drug delivery systems.
Hyaluronan is the most common negatively charged glycosaminoglycan in the human vitreous humor, and is known to interact with polymeric and liposomal DNA complexes, where hyaluronan solutions have been shown to decrease the cellular uptake of complexes.(4) This is useful for enhancing the availability and retention time of drugs administered to the eye. It is immunoneutral, which makes it useful for the attachment of biomaterials for use in tissue engineering and drug delivery systems; it also has important applications in the fields of vascosurgery and vascosupplementation.
Safety
Sodium hyaluronate is used in cosmetics and in topical, parenteral, and ophthalmic pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material. Sodium hyaluronate has been reported to be an experimental teratogen.LD50 (mouse, IP): 1.5 g/kg
LD50 (rabbit, IP): 1.82 g/kg
LD50 (rat, IP): 1.77 g/kg
저장
Sodium hyaluronate should be stored in a cool, dry place in tightly sealed containers. The powder is stable for 3 years if stored in unopened containers.Regulatory Status
Included in the FDA Inactive Ingredients Database (topical gel preparation).소듐하이알루로네이트 준비 용품 및 원자재
원자재
준비 용품
소듐하이알루로네이트 공급 업체
글로벌( 874)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 |
xie@china-sinoway.com | China | 1275 | 58 |
| ZhenYiBio Technology Inc | +8615309206328 |
alexxue@zhenyibio.com | China | 293 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21614 | 55 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2954 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 |
sales@zhswyy.com | China | 240 | 58 |
| Shanghai Enviko Biotechnologyg Co.,Ltd | +86-13918629532 +86-13918629532 |
info@envikobio.com | China | 239 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 |
Sibel@chuanghaibio.com | China | 8768 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 |
1059@dideu.com | China | 3588 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 |
faithe@yan-xi.com | China | 5853 | 58 |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 |
sales@kindchem.cn | China | 1226 | 58 |