눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313
노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P337+P313
눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
NFPA 704
0
2
0
포시노프릴나트륨 C화학적 특성, 용도, 생산
개요
Fosinopril sodium, an ester prodrug of fosinoprilat, is the first of a new generation of
phosphinic acid ACE inhibitors indicated for the once-daily treatment of hypertension.
Unlike captopril and lisinopril, it is reportedly effective in increasing the left
ventricular peak filling rates and peak ejection rates in hypertensive patients at rest.
Another advantage is that fosinopril sodium is metabolized equally by renal and hepatic
routes, thereby avoiding the requirement to modify dosage in patients with renal
insufficiency.
화학적 성질
White to Off-White Crystalline Solid
용도
Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
정의
ChEBI: The sodium salt of fosinopril. It is used for the treatment of hypertension and heart failure. A pro-drug, its phosphinate ester group is hydrolysed in vivo to give the corresponding phosphininc acid, fosinoprilat, which is the active metaboli
e.
일반 설명
Fosinopril sodium, (4S)-4-cyclohexyl-1-[[[(RS)-1-hydroxy-2-methylpropoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline sodium salt (Monopril),is a phosphorus-containing ACE inhibitor. It is inactive butserves as a prodrug, being completely hydrolyzed by intestinaland liver enzymes to the active diacid fosinoprilat.
