Atractylenolide-1
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Atractylenolide-1 속성
- 녹는점
- 121-123 °C(Solv: ligroine (8032-32-4))
- 끓는 점
- 405.0±44.0 °C(Predicted)
- 밀도
- 1.12
- 인화점
- 170℃
- 저장 조건
- 2-8°C
- 용해도
- 메탄올: 용해성1mg/mL, 투명, 무색
- 물리적 상태
- 가루
- 색상
- 하얀색
- 주요 응용
- 대사체학
비타민, 기능성 식품 및 천연 제품
- InChI
- InChI=1S/C15H18O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h8,12H,1,4-7H2,2-3H3/t12-,15+/m0/s1
- InChIKey
- ZTVSGQPHMUYCRS-SWLSCSKDSA-N
- SMILES
- O1C(=O)C(C)=C2C[C@]3([H])[C@@](C)(C=C12)CCCC3=C
안전
| WGK 독일 | 3 | ||
|---|---|---|---|
| 스토리지 클래스 | 11 - Combustible Solids |
Atractylenolide-1 C화학적 특성, 용도, 생산
개요
Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.Atractylenolide-1 준비 용품 및 원자재
원자재
준비 용품
Atractylenolide-1 공급 업체
글로벌( 267)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +86-18629295024 |
qinhe02@xaltbio.com | China | 996 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3618 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 |
scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +86-18080483897 |
sales@biopurify.com | China | 4616 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1922 | 58 |
| career henan chemical co | +86-0371-86658258 |
factory@coreychem.com | China | 29780 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 |
sales@chemnorm.com | CHINA | 2934 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32431 | 58 |
| Hubei Ipure Biology Co., Ltd | +8618062405514 |
ada@ipurechemical.com | China | 10224 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 |
info@aktinchem.com | CHINA | 1025 | 58 |