Ki8751
|
|
Ki8751 속성
- 녹는점
- 239℃
- 밀도
- 1.429
- 저장 조건
- −20°C
- 용해도
- DMSO에 용해됨(15 mg/ml)
- 물리적 상태
- 회백색 고체
- 색상
- 하얀색
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChI
- 1S/C24H18F3N3O4/c1-32-22-11-15-20(12-23(22)33-2)28-8-7-21(15)34-14-4-6-19(17(27)10-14)30-24(31)29-18-5-3-13(25)9-16(18)26/h3-12H,1-2H3,(H2,29,30,31)
- InChIKey
- LFKQSJNCVRGFCC-UHFFFAOYSA-N
- SMILES
- Fc1c(ccc(c1)F)NC(=O)Nc2c(cc(cc2)Oc3c4c(ncc3)cc(c(c4)OC)OC)F
안전
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-38 | ||
| 안전지침서 | 37 | ||
| WGK 독일 | WGK 1 | ||
| 스토리지 클래스 | 11 - Combustible Solids |
Ki8751 C화학적 특성, 용도, 생산
용도
Ki8751 is a potent and selective inhibitor of VEGFR2, PDGFRα and c-Kit with IC50 of 0.9 nM, 67 nM and 40 nM, respectively.일반 설명
A cell-permeable quinolyloxyphenyl-urea compound that acts as a VEGFR-2-selective inhibitior in both cell-based (IC50 = 0.9 nM in VEGF-induced receptor phosphorylation) and cell-free (IC50 = 4.0 nM in kinase reactions) assays. It inhibits c-Kit, PDGFRα, and FGFR-2 only at much higher concentrations (IC50 = 40, 67, and 170 nM, respectively, in cell-based assays), while exhibiting no effect against eight other commonly studied receptor and non-receptor kinases even at concentrations as high as 10 μM. Effectively blocks VEGF-dependent, but not VEGF-independent, cell proliferation in vitro and tumor growth in mice and rats (5 to 20 mg/kg, daily p.o.) in vivo.생물학적 활성
Potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC 50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFR α and FGFR-2 (IC 50 values range from 40 to 170 nM) but is highly selective over other receptor tyrosine kinases (IC 50 > 10000 nM for FGFR-2, EGFR and HGFR). Inhibits VEGF-stimulated proliferation of human umbilical vein endothelial cells (HUVEC) and inhibits tumor growth in vivo ; antiangiogenic.Ki8751 준비 용품 및 원자재
원자재
준비 용품
Ki8751 공급 업체
글로벌( 160)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | |
sales@boylechem.com | China | 2915 | 55 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 |
3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 |
sales@BioChemBest.com | China | 5996 | 61 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 |
sales@trio-pharmatech.com | China | 1856 | 62 |
| BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 9920 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 |
sales@meilune.com | China | 4765 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
China | 1490 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 |
info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 |
anhua.mao@aladdin-e.com | China | 29977 | 65 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 |
sales@fortunechem-sh.com | China | 981 | 58 |