6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials
Hazard Classifications
Acute Tox. 2 Oral
독성
LD50 i.p. in mice: 3 mg/kg (Jarboe)
그림문자(GHS):
신호 어:
Danger
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H300
삼키면 치명적임
급성 독성 물질 - 경구
구분 1,2
위험
P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
PICROTOXININ C화학적 특성, 용도, 생산
Biochem/physiol Actions
GABAA receptor antagonist; binds to the GABA receptor-linked Cl channel.
효소 저해제
These neurotoxic GABAA receptor antagonists, consisting of a nearly 1:1
mixture of picrotoxinin, (FW = 292.29 g/mol; CAS 17617-45-7) and
picrotin (FW = 310.30 g/mol; CAS 124-87-8), is a bitter-tasting (hence the
Greek prefix picros) principle, also known as cocculin, from fishberry seeds
(Anamirta cocculus) and the Philippine bayating (Tinomiscium
philippinense). Picrotoxin binds to the chloride channel of the receptor
without displacing g-aminobutyric acid. Picrotoxin is highly toxic,
exerting both stimulant and convulsant effects, and care must be exercised
when handling this agent.
