Mezlocillin
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Mezlocillin 속성
- 밀도
- 1.63±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 산도 계수 (pKa)
- pKa 2.7 (Uncertain)
- CAS 데이터베이스
- 51481-65-3(CAS DataBase Reference)
안전
Mezlocillin C화학적 특성, 용도, 생산
개요
Mezlocilin is an acylaminopenicillin, which has been shown to cause both immediate and delayed hypersensitivity in a nurse.용도
Like azlocillin, mezlocillin is used for infections of the urinary tract, gynecological infections, intraabdominal infections, skin infections, and respiratory tract infections. Synonyms of this drug are baypen, mezlin, and optocillin.정의
ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido group.Antimicrobial activity
A semisynthetic acylureidopenicillin supplied as the sodium salt for parenteral administration.Ampicillin-susceptible strains of H. influenzae and Neisseria spp. are very susceptible, but β-lactamase-producing organisms are usually resistant. It is less active than azlocillin and piperacillin against Ps. aeruginosa and has variable activity against B. fragilis, independent of β-lactamase production. It exhibits typical β-lactam synergy with aminoglycosides against Ps. aeruginosa and enterobacteria.
It attains peak concentrations of 250 mg/L after a 2 g intravenous infusion, with a plasma half-life of 55 min. Protein binding is 20–30%. It distributes into multiple tissues and human body fluids at therapeutically useful concentrations. Up to 60% of the dose is recoverable unchanged from the urine, with up to 2.5% excreted in the bile.
Toxicity and side effects are similar to those associated with carboxypenicillins. Its clinical use is for serious infections with susceptible organisms, including lower respiratory tract, intra-abdominal, urinary tract and gynecological infections. Commercial availability is quite limited.
일반 설명
Mezlocillin was synthesized by Bayer in 1974. The NH2 residue of ampicillin was acylated. Mezlocillin is a member of the so-called ureidopenicillins and shows two- to eightfold greater activity against Citrobacter, Enterobacter, Klebsiella, Escherichia coli, and Haemophilus influenzae than ampicillin, carbenicillin, or sulbenicillin. Its activity against gram-positive bacteria is almost the same as that of carbenicillin. Mezlocillin is used by intravenous administration for therapy of sepsis, meningitis, and respiratory tract, urinary tract, and abdominal infections.Mezlocillin 준비 용품 및 원자재
원자재
준비 용품
Mezlocillin 공급 업체
글로벌( 143)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 |
info@hanhongsci.com | China | 42917 | 64 |
| Wuhan Fortuna Chemical Co., Ltd | 027-59207852 13308628970 |
buy@fortunachem.com | China | 2698 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12323 | 58 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 |
sales@sunlidabio.com | China | 3223 | 55 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 |
cdhxsj@163.com | China | 13323 | 58 |
| Shanghai YuLue Chemical Co., Ltd. | 021-60345187 13671753212 |
lzz841106@aliyun.com | China | 10244 | 55 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 |
1400878000@qq.com | China | 9506 | 58 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 |
sales@altasci.com.cn | China | 4508 | 55 |
| Chengdu RunZeBenTu Chemical Co., Ltd | 028-88469284 18000562381; |
rzbtsj@163.com | China | 9939 | 56 |
| Nanjing Abix Biochemical Technology Co., Ltd. | 025-87193546 18652950785; |
chemweiao@163.com | China | 9009 | 60 |