4-Methylpyrazole manufacturers and suppliers

4-Methylpyrazole suppliers

Properties

Melting point:: 13°C

Boiling point:: 99-100 °C6 mm Hg(lit.)

Density: 0.993 g/mL at 25 °C(lit.)

vapor pressure: 7.136-87.85Pa at 20-50℃

refractive index: n20/D 1.495(lit.)

Flash point:: 205 °F

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

solubility: soluble

pka: 14.95±0.50(Predicted)

form: Liquid After Melting

color: Clear colorless to yellow

Specific Gravity: 0.993

Water Solubility: soluble

Sensitive: Hygroscopic

Merck: 14,4226

BRN: 105204

InChI: 1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)

InChIKey: RIKMMFOAQPJVMX-UHFFFAOYSA-N

SMILES: Cc1cn[nH]c1

LogP: 1.097 (est)

CAS DataBase Reference: 7554-65-6(CAS DataBase Reference)

NIST Chemistry Reference: 4-methylpyrazole(7554-65-6)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

target organs: Respiratory system

PPE: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes: Xn

Risk Statements: 22-36/37/38

Safety Statements: 26-36-24/25

RIDADR: 2810

WGK Germany: 3

RTECS: UQ7350000

F: 10-23

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29331990

Storage Class: 10 - Combustible liquids

Hazard Classifications: Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Toxicity: LD50 (7 days) in mice, rats (mmol/kg): 3.8, 3.8 i.v.; 7.8, 6.5 orally (Magnusson)

Use

Fomepizole is the first drug indicated as an antidote for ethylene glycol poisoning (it has also shown promise as a treatment for methanol poisoning). Fomepizole is 4-methyl-1H-pyrazole active as a synthetic alcohol dehydrogenase inhibitor, blocking the formation of toxic ethylene glycol metabolites which are responsible for a severe metabolic acidosis and renal failure. In limited human studies, it reversed the toxicity of potentially lethal doses of ethylene glycol. The main urinary metabolite has been reported to be 4-carboxypyrazole by oxidation of the methyl group. Compared with the current treatment (ethanol), the duration of action is longer and the safety is improved, with no toxic effects reported.

You can find 4-Methylpyrazole suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.