Diltiazem hydrochloride manufacturers and suppliers

Diltiazem hydrochloride suppliers

Properties

Melting point:: 212-214 °C

alpha: D24 +98.3 ± 1.4° (c = 1.002 in methanol)

Density: 1.30 g/cm3

refractive index: 118 ° (C=1, H2O)

Flash point:: 2℃

storage temp.: 2-8°C

solubility: Freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol.

form: Powder

color: White to off-white

PH: pH (10g/l, 25℃) : 4.3～5.3

Water Solubility: soluble

Merck: 13,3226

BRN: 4228706

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

CAS DataBase Reference: 33286-22-5(CAS DataBase Reference)

EPA Substance Registry System: 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2S,3S)- (33286-22-5)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P301+P312+P330

Hazard Codes: Xn,Xi,F

Risk Statements: 22-40-36/37/38-36-20/21/22-11

Safety Statements: 36-45-36/37-26-16

RIDADR: 3249

WGK Germany: 3

RTECS: DL0310000

F: 8-10

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29349990

Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)

Use

Diltiazem hydrochloride was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.

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