Rofecoxib manufacturers and suppliers

Rofecoxib suppliers

Properties

Melting point:: 207°C

Boiling point:: 577.6±50.0 °C(Predicted)

Density: 1.333±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO: soluble5mg/mL, clear (warmed)

form: powder

color: white to beige

Water Solubility: 9mg/L(25 ºC)

Merck: 14,8248

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

InChI: 1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3

InChIKey: RZJQGNCSTQAWON-UHFFFAOYSA-N

SMILES: [S](=O)(=O)(C)c1ccc(cc1)C2=C(C(=O)OC2)c3ccccc3

CAS DataBase Reference: 162011-90-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P501-P270-P264-P301+P312+P330

Hazard Codes: Xn

Risk Statements: 22

WGK Germany: 3

RTECS: LU5135000

HS Code: 2932.20.3000

Storage Class: 11 - Combustible Solids

Hazard Classifications: Acute Tox. 4 Oral

Hazardous Substances Data: 162011-90-7(Hazardous Substances Data)

Use

Rofecoxib ts a non-steroidal anti-inflammatory drug (NSAID) launched in Mexico, its first market, for the management of acute pain and the treatment of osteoarthritis (OA) and primary dysmenorrhea. Rofecoxib can be obtained by several different ways; one example is by arylation of a 4-bromofuranone with a phenylboronic acid under Suzuki conditions. Rofecoxib is a highly selective inhibitor of COX-2, the inducible isoform of cyclooxygenase and therefore exhibits a potent antiinflammatory activity without concomitant gastric or renal toxicities linked to the non-specific COX-1/2 inhibitors. In several clinical studies in patients with knee or hip osteoarthritis, Rofecoxib was evaluated at 12.5-50 mg doses once daily: it demonstrated efficacy for all primary and secondary endpoints at doses considerably weaker than those for classical non-specific NSAIDs, with good tolerance and less adverse effects. Selective COX-2 inhibitors potentially have a large spectrum of activity including new indications such as Alzheimer's disease, colorectal cancer, irritable bowel disease or urinary incontinence.

You can find Rofecoxib suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.