ABT-263 suppliers
ABT 263
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Properties
- Melting point:
- 114-116°C
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- solid
- pka
- 4.60±0.10(Predicted)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChIKey
- JLYAXFNOILIKPP-KXQOOQHDSA-N
- SMILES
- C(NS(C1=CC=C(N[C@@H](CSC2=CC=CC=C2)CCN2CCOCC2)C(S(C(F)(F)F)(=O)=O)=C1)(=O)=O)(=O)C1=CC=C(N2CCN(CC3CC(C)(C)CCC=3C3=CC=C(Cl)C=C3)CC2)C=C1
- CAS DataBase Reference
- 923564-51-6
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H303-H320
- Precautionary statements
- P312-P264-P305+P351+P338-P337+P313
- HS Code
- 29339900
Use
ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 M. All four cell lines with EC50 values of 400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263.
170 supplier list of "ABT 263"
- Product Name:ABT263
- Products Intro:Purity: 98% (Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:ABT 263
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Navitoclax
- Products Intro:Purity: 98% | Package: 100 mg | CustNote: Please reach out to us for more information about custom solutions.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:abt 263
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Navitoclax
- Products Intro:Package: 25KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Phytic acid,Ortho Nitrobenzaldehyde,Phthalide,4-Cyanophenol,P-tert-Butyl Benzoic Acid(PTBBA)
$39.00-84.00
- Product Name:Navitoclax
- Products Intro:Purity: 99.67% | Package: 5mg;41USD|10mg;57USD|25mg;88USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:ABT 263
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA
- Product Name:ABT-263 Navitoclax
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: ABT263
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms
- Product Name:ABT 263
- Products Intro:Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: pharmaceuticals,intermediates,fine chemicals,screening compounds,building blocks