Alvimopan manufacturers and suppliers

Alvimopan suppliers

Properties

Melting point:: 200-204°C

Boiling point:: 684.1±55.0 °C(Predicted)

Density: 1.166±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO (Slightly), Methanol (Slightly, Sonicated, Heated)

form: Solid

pka: 3.39±0.10(Predicted)

color: White

optical activity: [α]/D +46 to +52°, c =1.0 in DMSO

InChIKey: UPNUIXSCZBYVBB-JVFUWBCBSA-N

SMILES: C[C@H]1CN(C[C@@H](C(NCC(O)=O)=O)CC2=CC=CC=C2)CC[C@]1(C3=CC=CC(O)=C3)C

Safety Information

Symbol(GHS): GHS07,GHS09

Signal word: Warning

Hazard statements: H315-H319-H400

Precautionary statements: P273-P302+P352-P305+P351+P338

WGK Germany: WGK 3

Storage Class: 11 - Combustible Solids

Hazard Classifications: Aquatic Acute 1
Eye Irrit. 2
Skin Irrit. 2

Hazardous Substances Data: 156053-89-3(Hazardous Substances Data)

Use

Alvimopan has its chemical name being 2-[[(2S)-2-[[(3R, 4R)-4-(3-hydroxyphenyl)-3, 4-dimethyl-piperidin-1-yl] methyl]-3-phenyl-propionyl] amino] acetic acid dihydrate. It is a highly selective peripheral opioid antagonist which was jointly developed by the British company GlaxoSmithKline (GSK) and the United States Adolor company. In May 2008, it was approved by the US FDA for entering into market for applying to promote the recovering of the gastrointestinal function of patients who have been subject to colon or small intestine stage I resection anastomosis. Since the product can selectively inhibit the gastrointestinal opioid receptors without reducing the central analgesic effect of opioid agonists, therefore it does not affect the analgesic effect of systemic administration with safety and well-tolerance.

You can find Alvimopan suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.