ApreMilast manufacturers and suppliers

Apremilast suppliers

Properties

Melting point:: 152-156°C

Boiling point:: 741.3±60.0 °C(Predicted)

Density: 1.381

storage temp.: Refrigerator

solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)

form: Solid

pka: 14.01±0.20(Predicted)

color: White to Pale Yellow

InChI: 1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1

InChIKey: IMOZEMNVLZVGJZ-QGZVFWFLSA-N

SMILES: C(NC1=CC=CC2=C1C(=O)N([C@@H](C1=CC=C(OC)C(OCC)=C1)CS(C)(=O)=O)C2=O)(=O)C

CAS DataBase Reference: 608141-41-9

Safety Information

Symbol(GHS): GHS08,GHS07

Signal word: Warning

Hazard statements: H302-H361

Precautionary statements: P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501

WGK Germany: WGK 3

Storage Class: 11 - Combustible Solids

Hazard Classifications: Acute Tox. 4 Oral
Repr. 2
STOT SE 2

Hazardous Substances Data: 608141-41-9(Hazardous Substances Data)

Use

Apremilast (Otezla) was approved by the FDA on March 21, 2014 for the treatment of adult patients with active psoriatic arthritis. Apremilast is a member of a new class of oral small molecule inhibitors of the phosphosphodiesterase 4 (PDE4) enzyme. When PDE4 is inhibited in immune cells, it results in elevation of intracellular cyclic adenosine monophosphate (cAMP) levels, which can regulate inflammatory mediators. The current clinical data indicate that apremilast is an effective and well tolerated option for the management of psoriasis and PsA in adults.

You can find Apremilast suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.