Captopril manufacturers and suppliers

Captopril suppliers

Properties

Melting point:: 104-108 °C (lit.)

alpha: -129.5 º (c=1, EtOH)

Boiling point:: 427.0±40.0 °C(Predicted)

Density: 1.2447 (rough estimate)

refractive index: -127.5 ° (C=1.7, EtOH)

storage temp.: room temp

solubility: H₂O: 0.1 g/mL, very slightly hazy, colorless

pka: 3.7, 9.8(at 25℃)

form: Crystalline Powder

color: white to off-white

biological source: synthetic (organic)

optical activity: -112.8°(C=0.01g/ml ETOH)

Water Solubility: soluble

Merck: 14,1774

BRN: 477887

BCS Class: 3

Stability:: Stable. Incompatible with strong oxidizing agents.

InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChIKey: FAKRSMQSSFJEIM-RQJHMYQMSA-N

SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

CAS DataBase Reference: 62571-86-2(CAS DataBase Reference)

NIST Chemistry Reference: Captopril(62571-86-2)

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H341-H360F

Precautionary statements: P201-P308+P313

PPE: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes: Xn,Xi

Risk Statements: 43-63-36/37/38-40

Safety Statements: 36/37-37/39-26-36-22

WGK Germany: 2

RTECS: UY0550000

HS Code: 29339900

Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications: Muta. 2
Repr. 1B

Hazardous Substances Data: 62571-86-2(Hazardous Substances Data)

Toxicity: LD50 in mice (mg/kg): 1040 i.v.; 6000 orally (Keim)

Use

Captopril, 1-[(2S)-3-mercapto-2-methyl-1-oxopropionyl]proline (Capoten), blocks the conversion of angiotensinI to angiotensin II by inhibiting the convertingenzyme. The rational development of captopril as an inhibitorof ACE was based on the hypothesis that ACE and carboxypeptidaseA functioned by similar mechanisms. It wasnoted that d-2-benzylsuccinic acid was a potent inhibitor ofcarboxypeptidase A, but not ACE. By use of this small molecule as a prototype, captopril was designed with a carboxylgroup on a proline and a thiol group was introduced toenhance the binding to the zinc ion of ACE. The importantbinding points at the active site of ACE are thought to be anarginine residue, which provides a cationic site that attracts acarboxylate ion, and a zinc ion, which can polarize a carbonylgroup of an amide function to make it more susceptible to hydrolysis.Hydrophobic pockets lie between these groups in theactive site, as does a functional group that forms a hydrogenbond with an amide carbonyl.

You can find Captopril suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.