CITRININ manufacturers and suppliers

CITRININ suppliers

Properties

Melting point:: 175°C (dec.)

alpha: D18 -37.4° (c = 1.15 in alc.)

Boiling point:: 313.38°C (rough estimate)

Density: 1.37

refractive index: 1.4560 (estimate)

Flash point:: 2℃

storage temp.: 2-8°C

solubility: ≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide

pka: 1.52±0.60(Predicted)

form: Crystalline Powder or Flakes

color: Yellow

biological source: rabbit

Merck: 13,2351

BRN: 5282243

Stability:: Hygroscopic

Major Application: cleaning products
cosmetics
food and beverages
personal care

InChI: 1S/C13H14O5/c1-5-7(3)18-4-8-9(5)6(2)11(14)10(12(8)15)13(16)17/h4-5,7,15H,1-3H3,(H,16,17)/t5-,7-/m1/s1

InChIKey: CQIUKKVOEOPUDV-IYSWYEEDSA-N

SMILES: C[C@H]1OC=C2C(O)=C(C(O)=O)C(=O)C(C)=C2[C@@H]1C

CAS DataBase Reference: 518-75-2(CAS DataBase Reference)

IARC: 3 (Vol. 40, Sup 7) 1987

EPA Substance Registry System: Citrinin (518-75-2)

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301+H311+H331-H351

Precautionary statements: P202-P261-P280-P301+P310-P302+P352+P312-P304+P340+P311

Hazard Codes: T

Risk Statements: 23/24/25-40-36/37/38

Safety Statements: 26-36/37/39-45-22-7/9

RIDADR: UN 3462 6.1/PG 3

WGK Germany: 3

RTECS: DJ2275000

HazardClass: 6.1(a)

PackingGroup: II

HS Code: 29419090

Storage Class: 3 - Flammable liquids

Hazard Classifications: Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 2

Hazardous Substances Data: 518-75-2(Hazardous Substances Data)

Toxicity: LD50 in mice, rats (mg/kg): 35, 67 i.p. (Ambrose, De Eds)

Use

Citrinin is a quinonemethine mycotoxin produced by diverse fungi including Aspergillus and Penicillium. Citrinin has been extensively investigated and is a potent nephrotoxin with hepatoxic and teratogenic activity. Citrinin is the causative agent of Balkan nephropathy and yellow rice fever in humans. At the molecular level, citrinin exhibits a range of effects including free radical damage to DNA and disruption of mitochondrial membrane-bound enzymic activities and structural integrity. Specifically, citrinin is an inhibitor of NADH dehydrogenase in the mitochondrial electron transport chain and this action is responsible for recent reports of citrinin's apoptotic activity.

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