Clevudine manufacturers and suppliers

Clevudine suppliers

Properties

Melting point:: 184-185°

alpha: D25 -111.77° (c = 0.23 in methanol)

Density: 1.55±0.1 g/cm3(Predicted)

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C

solubility: DMSO (Slightly), Methanol (Slightly)

form: Solid

pka: 9.55±0.10(Predicted)

color: White

InChI: InChI=1/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/s3

InChIKey: GBBJCSTXCAQSSJ-DFVSTPOWNA-N

SMILES: [C@@H]1(O[C@@H](CO)[C@H](O)[C@H]1F)N1C=C(C(=O)NC1=O)C |&1:0,2,5,7,r|

CAS DataBase Reference: 163252-36-6

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H332-H335

Precautionary statements: P280-P305+P351+P338-P310

Toxicity: LD50 in mice, rats (mg/kg): >5000, >3000 orally (Painter)

Use

Clevudine is a fluorinated b-l-nucleoside analog launched for the oral treatment of chronic hbv infection. it is the fifth nucleoside or nucleotide analog to be marketed for this indication. the previous drugs from this class include lamivudine, adefovir, entecavir, and telbivudine. in hbv-expressing human hepatoma cell line 2.2.15, clevudine inhibits hbv dna synthesis with an ec50 of 0.1 μm, and does not show cytotoxicity up to 200 μm.

You can find Clevudine suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.