Entacapone suppliers
Entacapone
- CAS:
- 130929-57-6
- MF:
- C14H15N3O5
- MW:
- 305.29
Suppliers by country/region
Company Type
Properties
- Melting point:
- 162-1630C
- Boiling point:
- 526.6±50.0 °C(Predicted)
- Density
- 1.392±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- pKa ~4.5(at 25℃)
- color
- white to light brown
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- InChI
- InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5+
- InChIKey
- JRURYQJSLYLRLN-BJMVGYQFSA-N
- SMILES
- C(N(CC)CC)(=O)/C(/C#N)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1
- CAS DataBase Reference
- 130929-57-6(CAS DataBase Reference)
Safety Information
- Symbol(GHS)
GHS07
- Signal word
- Warning
- Hazard statements
- H315-H319
- Precautionary statements
- P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
- WGK Germany
- 3
- HS Code
- 2926900005
- Storage Class
- 11 - Combustible Solids
- Hazardous Substances Data
- 130929-57-6(Hazardous Substances Data)
Use
Entacapone was introduced in Finland, Germany and Sweden as an adjunctive treatment with L-dopa in Parkinson’s disease. Entacapone is the second drug in its class to reach the market; it can be obtained by basecatalyzed condensation of the corresponding benzaldehyde with a cyanoacetamide. Entacapone is a highly selective and orally-active catechol-0- methyltransferase (COMT) inhibitor ; by inhibiting metabolism of L-dopa when given as an adjuvant in patients with Parkinson’s disease, Entacapone markedly prolongs the effects of L-dopa and improves its bioavailability. Results from clinical studies showed that 200mglday Entacapone coadministered with L-dopa lowered the dose of the latter required to reduce fluctuations in motor performance.
393 supplier list of "Entacapone"
- Product Name:(E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide
- Products Intro:Purity: 98%(Min.HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:(E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide
- Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
$2.00/ 1kg
- Product Name:Entacapone
- Products Intro:Purity: 99% | Package: 1kg;2USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
- Product Name:Entacapone
- Products Intro:Purity: >98% | Package: 500 mg | CustNote: Reach out to us for more information about custom solutions.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:entacapone
- Products Intro:Purity: 0.99 | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA
$30.00-73.00 / 5mg
- Product Name:Entacapone
- Products Intro:Purity: 99.79% | Package: 5mg;30USD|10mg;47USD|25mg;73USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:Entacapone
- Products Intro:Purity: 0.99 | Package: 5KG;1KG
- Company Type: Trader
- Country/Region: CHINA
- Product Name:Entacapone
- Products Intro:Purity: 99.9%|Package: 1g
- Company Type: Trader
- Country/Region: CHINA
- Product Name:entacapone
- Products Intro:Purity: 99% | Package: USP EP CP
- Company Type: Trader
- Country/Region: CHINA
- Main Products: Pharmceutical,Optical Brightening,dyes
- Product Name:Entacapone
- Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: Entacapone
- Company Type: Trader
- Country/Region: CHINA
- Main Products: sarms