Flurbiprofen manufacturers and suppliers

Flurbiprofen suppliers

Properties

Melting point:: 110-112 °C(lit.)

Boiling point:: 376.2±30.0 °C(Predicted)

Density: 1.1795 (estimate)

storage temp.: Sealed in dry,Room Temperature

solubility: methanol: soluble50mg/mL

pka: pKa 3.80(H2O) (Uncertain)

form: White solid

color: white to off-white

biological source: synthetic

Water Solubility: 8mg/L(room temperature)

Merck: 14,4199

InChI: InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)

InChIKey: SYTBZMRGLBWNTM-UHFFFAOYSA-N

SMILES: FC1C=C(C=CC=1C1C=CC=CC=1)C(C)C(=O)O

CAS DataBase Reference: 5104-49-4(CAS DataBase Reference)

EPA Substance Registry System: [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-?-methyl- (5104-49-4)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P264-P270-P301+P310+P330-P405-P501

Hazard Codes: T,C

Risk Statements: 25-23/24/25

Safety Statements: 36/37/39-45

RIDADR: UN 2811 6.1/PG 2

WGK Germany: 3

RTECS: DU8341000

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29163990

Limited Quantities: 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Use

Flurbiprofen (Ansaid, Ocufen, Froben), is another drug inthis class indicated for both acute and long-term managementof RA and OA but with a more complex mechanism ofaction. Unlike the other drugs in this class, it does not undergochiral inversion (i.e., the conversion of the “inactive”[R]-enantiomer to the active, [S]-enantiomer). Similar to aspirinand other salicylates, both flurbiprofen enantiomersblock COX-2 induction as well as inhibiting the nuclearfactor-κB-mediated polymorphonuclear leukocyte apoptosissignaling; therefore, both enantiomers are believed to contributeequally to its overall anti-inflammatory action.(R)-flurbiprofen is actually a strong clinical candidate forthe treatment of Alzheimer disease, because it has beenshown to reduce Aβ42 production by human cells.

You can find Flurbiprofen suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.