Geldanamycin manufacturers and suppliers

Geldanamycin suppliers

Properties

Melting point:: 255 °C

Boiling point:: 627.87°C (rough estimate)

Density: 1.2443 (rough estimate)

refractive index: 1.5800 (estimate)

Flash point:: 87℃

storage temp.: -20°C

solubility: DMSO: soluble

pka: 8.42±0.70(Predicted)

form: powder

color: yellow to orange

biological source: Streptomyces hygroscopicus

λmax: 305nm(MeOH)(lit.)

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months

InChIKey: QTQAWLPCGQOSGP-KSRBKZBZSA-N

SMILES: C1(OC)C(=O)C=C2NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)N)C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC=1C2=O |c:13,t:11,24|

CAS DataBase Reference: 30562-34-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H303-H227

Precautionary statements: P210e-P280a-P370+P378a-P403+P235-P501a

PPE: Eyeshields, Gloves, type N95 (US)

Hazard Codes: T,Xi

Risk Statements: 36/37/38

Safety Statements: 26-27-36/37/39-24/25

WGK Germany: 2

RTECS: LX8920000

HS Code: 29419090

Storage Class: 11 - Combustible Solids

Use

Geldanamycin is benzoquinone ansamycin antibiotic isolated from Streptomyces hygroscopicus. It is a potent antitumor metabolite that acts by binding to the 90-kDa heat-shock protein (Hsp90) essential to maintain the conformation, stability, activity and cellular localisation of several key oncogenic proteins such as ERBB2, C-RAF, CDK4, AKT/PKB, steroid hormone receptors, mutant p53, HIF-1α, survivin and telomerase hTERT.

You can find Geldanamycin suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.