Imipramine hydrochloride manufacturers and suppliers

Imipramine hydrochloride suppliers

Properties

Melting point:: 168-1700C

Flash point:: 9℃

storage temp.: 2-8°C

solubility: H₂O: 50 mg/mL

form: crystalline

color: white

PH: 4.2～5.2(100g/l,25℃)

Water Solubility: Soluble in water

λmax: 260nm(lit.)

Merck: 14,4920

CAS DataBase Reference: 113-52-0(CAS DataBase Reference)

EPA Substance Registry System: 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride (113-52-0)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300

Precautionary statements: P264-P270-P301+P310-P405-P501

Hazard Codes: Xn,T,F

Risk Statements: 23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11

Safety Statements: 7-16-24-33-45-36-26-36/37

RIDADR: UN 1230 3/PG 2

WGK Germany: 3

RTECS: HO1925000

TSCA: Yes

HS Code: 2933995800

Toxicity: LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe)

Use

Imipramine hydrochloride, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride(Tofranil), is the lead compound of the TCAs. It is also a closerelative of the antipsychotic phenothiazines (replace the10–11 bridge with sulfur, and the compound is the antipsychoticagent promazine). It has weaker D2 postsynaptic blockingactivity than promazine and mainly affects amines (5-HT,NE, and DA) via the transporters. As is typical of dimethylaminocompounds, anticholinergic and sedative (central H1block) effects tend to be marked. The compound per se has a tendency toward a high 5-HT-to-NE uptake block ratio andprobably can be called a serotonin transport inhibitor(SERTI). Metabolic inactivation proceeds mainly by oxidativehydroxylation in the 2-position, followed by conjugationwith glucuronic acid of the conjugate. Urinary excretion predominates(about 75%), but some biliary excretion (up to25%) can occur, probably because of the large nonpolargrouping. Oxidative hydroxylation is not as rapid or completeas that of the more nucleophilic ring phenothiazine antipsychotics;consequently, appreciable N-demethylation occurs,with a buildup of norimipramine (or desimipramine).

You can find Imipramine hydrochloride suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.