Indometacin manufacturers and suppliers

Indometacin suppliers

Properties

Melting point:: 158-162 °C

Boiling point:: 499.4±45.0 °C(Predicted)

Density: 1.2135 (rough estimate)

refractive index: 1.6800 (estimate)

storage temp.: Store at RT

solubility: ethanol: 50 mg/mL, clear, yellow-green

pka: 4.5(at 25℃)

form: White to off-white powder

color: White to Light yellow to Light orange

biological source: synthetic

Water Solubility: Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.

Sensitive: Light Sensitive

Merck: 14,4968

BRN: 497341

BCS Class: 2

Stability:: Stable. Incompatible with strong oxidizing agents.

InChI: 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

InChIKey: CGIGDMFJXJATDK-UHFFFAOYSA-N

SMILES: COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

CAS DataBase Reference: 53-86-1(CAS DataBase Reference)

NIST Chemistry Reference: Indomethacin(53-86-1)

EPA Substance Registry System: Indomethacin (53-86-1)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300

Precautionary statements: P264-P301+P310

PPE: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes: T+,Xi,T

Risk Statements: 28-36/37/38-39/23/24/25-23/24/25

Safety Statements: 28-36/37-45-36-26

RIDADR: UN 2811 6.1/PG 1

WGK Germany: 3

RTECS: NL3500000

F: 8-10

TSCA: TSCA listed

HazardClass: 6.1

PackingGroup: I

HS Code: 29339900

Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications: Acute Tox. 1 Oral

Hazardous Substances Data: 53-86-1(Hazardous Substances Data)

Toxicity: LD50 i.p. in rats: 13 mg/kg (Klaassen)

REACH Registrations: Active

Excepted Quantities: Max Inner Pack (1g or 1ml) and Max Outer Pack (300g or 300ml)

Use

Indometacin was introduced in 1963 and it is one of the first NSAIDs. Convulsions are rarely reported in relation with the use of this group of agents. Indometacin farnesil is a pro-drug of indometacin, and the occurrence of gastro-intestinal adverse effects could be expected. See also under nonsteroidal antiinflammatory agents.

You can find Indometacin suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.