Lamotrigine manufacturers and suppliers

Lamotrigine suppliers

Properties

Melting point:: 177-181°C

Boiling point:: 503.1±60.0 °C(Predicted)

Density: 1.572±0.06 g/cm3(Predicted)

Flash point:: 9℃

storage temp.: 2-8°C

solubility: DMSO: 20 mg/mL at 60 °C, soluble

pka: 5.7(at 25℃)

form: powder

color: white

Merck: 14,5353

BCS Class: 2

InChI: InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

InChIKey: PYZRQGJRPPTADH-UHFFFAOYSA-N

SMILES: N1C(C2=CC=CC(Cl)=C2Cl)=C(N)N=C(N)N=1

CAS DataBase Reference: 84057-84-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P264-P270-P301+P310-P405-P501

Hazard Codes: T,Xi,F

Risk Statements: 25-36/37/38-39/23/24/25-23/24/25-11

Safety Statements: 45-36-26-36/37-16

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: XY5850700

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 29336990

Hazardous Substances Data: 84057-84-1(Hazardous Substances Data)

Toxicity: LD50 in mice, rats (mg/kg): 250, >640 orally (Sawyer)

Use

With AEDs Plasma concentration of lamotrigine is increased by the glucuronidation inhibitor valproate (reduce lamotrigine dose to avoid increased risk of toxicity). Plasma concentration of lamotrigine is reduced by the glucuronidation inducers carbamazepine, phenytoin, phenobarbital and primidone. Lamotrigine can raise concentration of active metabolite of carbamazepine (conflicting evidence). With other drugs Plasma concentration of lamotrigine is reduced by the glucuronidation inducers oestrogens, rifampicin, and ritonavir (consider increasing the dose of lamotrigine). Plasma concentration of lamotrigine is possibly increased by desogestrel. With alcohol/food There are no known specific interactions between alcohol and lamotrigine, and there are no specific foods that must be excluded from diet when taking lamotrigine.

You can find Lamotrigine suppliers, manufacturers, and distributors from countries such as CHINA, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.