Letrozole manufacturers and suppliers

Letrozole suppliers

Properties

Melting point:: 181-183°C

Boiling point:: 563.5±60.0 °C(Predicted)

Density: 1.21±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: DMSO: >50mg/mL

pka: 1.52±0.11(Predicted)

form: White powder

color: white to off-white

Merck: 14,5450

InChI: InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H

InChIKey: HPJKCIUCZWXJDR-UHFFFAOYSA-N

SMILES: C(C1=CC=C(C=C1)C#N)(C1=CC=C(C=C1)C#N)N1C=NC=N1

CAS DataBase Reference: 112809-51-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H361fd-H373

Precautionary statements: P202-P260-P280-P308+P313-P405-P501

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

WGK Germany: 3

RTECS: DI4957000

HS Code: 2933997500

Storage Class: 11 - Combustible Solids

Hazard Classifications: Repr. 2
STOT RE 2

Hazardous Substances Data: 112809-51-5(Hazardous Substances Data)

Use

Letrozole, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)dibenzonitrile (Femara), is used for most of thesame indications as anastrozole. It reduces concentrations ofestrogens by 75% to 95%, with maximal suppressionachieved within 2 to 3 days. Letrozole is specific for aromataseinhibition, with no additional effects on adrenal corticoidbiosynthesis. CYPs 3A4 and 2A6 are involved in themetabolism of letrozole to the major carbinol metabolite,which is inactive. The loss of the triazole ring, which is involvedin coordination of the heme iron, would explain theloss of activity. Letrozole strongly inhibits CYP2A6 invitro, with moderate inhibition of CYP2C19. The effect ofthis in vitro inhibition on the pharmacokinetics of coadministereddrugs is unknown. Tamoxifen reduces the levels ofletrozole significantly if they are used together, so combinationtreatment with these agents is not recommended.

You can find Letrozole suppliers, manufacturers, and distributors from countries such as CHINA, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.