LY 2157299 manufacturers and suppliers

LY 2157299 suppliers

LY 2157299

CAS:: 700874-72-2

MF:: C22H19N5O

MW:: 369.42

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Properties

Melting point:: 241-242°C

Boiling point:: 619.0±55.0 °C(Predicted)

Density: 1.40

Flash point:: 328.162℃

storage temp.: -20°C

solubility: Soluble in DMSO (up to 25 mg/ml)

pka: 15.27±0.30(Predicted)

form: solid

color: White

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

InChI: InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)

InChIKey: IVRXNBXKWIJUQB-UHFFFAOYSA-N

SMILES: N1C2C(=CC(C(N)=O)=CC=2)C(C2C(C3=NC(C)=CC=C3)=NN3CCCC3=2)=CC=1

CAS DataBase Reference: 700874-72-2

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319

Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes: T

Risk Statements: 25

Safety Statements: 45

WGK Germany: WGK 3

HS Code: 29334900

Storage Class: 11 - Combustible Solids

Use

LY2157299 is a small molecule inhibitor of the TGF-β receptor type 1 kinase (IC50 = 56 nM). It has been used to study the role of TGF-β signaling in chemotherapy-induced expansion of cancer stem-like cells in triple negative breast cancer cell lines and xenografts. LY2157299 has also been shown to inhibit the migration and tumor growth of hepatocellular carcinoma cell lines by disrupting Smad-2 phosphorylation.[Cayman Chemical]

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