Megestrol acetate manufacturers and suppliers

Megestrol acetate suppliers

Properties

Melting point:: 214°C

Boiling point:: 431.17°C (rough estimate)

alpha: D24 +5° (chloroform)

Density: 1.0474 (rough estimate)

refractive index: 11 ° (C=2, CHCl3)

storage temp.: Sealed in dry,Room Temperature

solubility: Practically insoluble in water, soluble in acetone, sparingly soluble in alcohol.

form: Solid

color: White

Merck: 14,5805

BRN: 1917291

InChIKey: RQZAXGRLVPAYTJ-GQFGMJRRSA-N

SMILES: C1(=O)C=C2[C@](C)(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](OC(C)=O)(C(=O)C)CC3)C=C2C

CAS DataBase Reference: 595-33-5(CAS DataBase Reference)

NIST Chemistry Reference: Megestrol acetate(595-33-5)

EPA Substance Registry System: Megestrol acetate (595-33-5)

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H360FD

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

Hazard Codes: Xn

Risk Statements: 40-48

Safety Statements: 22-24/25

WGK Germany: 3

RTECS: TU4075000

HS Code: 29372390

Toxicity: LD50 intravenous in mouse: 56mg/kg

Use

Megestrol acetate, 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate(Megace), is a progestin used primarily for the palliativemanagement of recurrent, inoperable, or metastatic endometrialor breast carcinoma. Megestrol acetate has also beenindicated for appetite enhancement in patients with AIDS.The biochemical basis for this use of megestrol is unclear.

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