ML216 suppliers
ML216
- CAS:
- 1430213-30-1
- MF:
- C15H9F4N5OS
- MW:
- 383.32
Suppliers by country/region
Company Type
Properties
- Density
- 1.583±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:29.0(Max Conc. mg/mL);75.65(Max Conc. mM)
- pka
- 6.40±0.50(Predicted)
- form
- powder
- color
- light orange to dark orange
- InChI
- 1S/C15H9F4N5OS/c16-11-2-1-9(7-10(11)15(17,18)19)21-13(25)22-14-24-23-12(26-14)8-3-5-20-6-4-8/h1-7H,(H2,21,22,24,25)
- InChIKey
- WMCOYUSJXXCHFH-UHFFFAOYSA-N
- SMILES
- FC(F)(F)c1c(ccc(c1)NC(=O)Nc2[s]c(nn2)c3ccncc3)F
Safety Information
- Symbol(GHS)
GHS06
- Signal word
- Danger
- Hazard statements
- H301-H413
- Precautionary statements
- P273-P301+P310+P330
- Hazard Codes
- T
- Risk Statements
- 25
- Safety Statements
- 45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
- Storage Class
- 11 - Combustible Solids
Use
Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.[Cayman Chemical]
53 supplier list of "ML216"
$57.00-136.00
- Product Name:ML216
- Products Intro:Purity: 98.12% | Package: 5mg;57USD|10mg;86USD|25mg;136USD | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:ML216；CID-49852229
- Products Intro:Package: 10 mg；100 mg；25 mg；5 mg；50 mg | CustNote: REAGENT;FOR LABORATORY USE ONLY
- Company Type: Reagent
- Country/Region: UNITED STATES
- Main Products: Compound Libraries,Noval Small Molecucles,Nature Compounds,Inhibitory Antibodies,Life science Kits
- Product Name:ML216
- Products Intro:Purity: >=99% | Package: $71.9/5mg;$102.9/10mg;$165.9/25mg;$226.9/50mg;$325.9/100mg;$733.9/250mg;Bulk pac | CustNote: 99%
- Company Type: Trader
- Country/Region: UNITED STATES
- Main Products: Chemicals and BioChemicals,Materials Science,ligands acting on targets,Proteins,Antibodies
- Product Name:ML216
- Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A857038
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:ML216(CID-49852229)
- Products Intro:Brand：chiralstar | Product Number：scs-1561
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:ML216
- Products Intro:Brand:sigma aldrich | Product Number:SML0661 | Purity:≥98%(HPLC)
- Company Type: Trader
- Country/Region: INDIA
-
100mg$1353.00
- Products Intro:Brand:1pchem | Product Number:1P009CU4 | Purity:95%
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea
- Products Intro:Brand：Chemenu | Product Number：CM176425 | Purity：98%
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:ML216
- Products Intro:Brand：ChemShuttle
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]ure;.
- Products Intro:Brand：abcr | Product Number：AB511648
- Company Type: Trader
- Country/Region: UNITED STATES