Nalidixic acid manufacturers and suppliers

Nalidixic acid suppliers

Properties

Melting point:: 227-229 °C (lit.)

Boiling point:: 374.4°C (rough estimate)

Density: 1.2243 (rough estimate)

refractive index: 1.6660 (estimate)

storage temp.: 2-8°C

solubility: chloroform: 20 mg/mL, clear

pka: pKa 6.11± 0.02(Approximate)

form: Powder

color: White to light yellow

biological source: synthetic

Water Solubility: 0.1 G/L (23 ºC)

Merck: 14,6359

BRN: 750515

Stability:: Stable. Incompatible with strong oxidizing agents.

Major Application: clinical testing

InChI: 1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)

InChIKey: MHWLWQUZZRMNGJ-UHFFFAOYSA-N

SMILES: CCN1C=C(C(O)=O)C(=O)c2ccc(C)nc12

CAS DataBase Reference: 389-08-2(CAS DataBase Reference)

EPA Substance Registry System: Nalidixic acid (389-08-2)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H302-H351

Precautionary statements: P202-P264-P270-P280-P301+P312-P308+P313

Hazard Codes: Xn

Risk Statements: 63-42/43-40-20/21/22-22

Safety Statements: 22-36/37-45-24-36

WGK Germany: 2

RTECS: QN2885000

F: 8-10-23

HS Code: 29339190

Storage Class: 11 - Combustible Solids

Hazard Classifications: Acute Tox. 4 Oral
Carc. 2

Hazardous Substances Data: 389-08-2(Hazardous Substances Data)

Toxicity: LD50 in mice (mg/kg): 3300 orally; 500 s.c.; 176 i.v. (Lesher, 1962)

Use

1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (NegGram) occurs as a pale buff crystalline powder that is sparingly soluble in water and ether but solublein most polar organic solvents.Nalidixic acid is useful in the treatment of urinary tractinfections in which Gram-negative bacteria predominate.The activity against indole-positive Proteus spp. is particularlynoteworthy, and nalidixic acid and its congeners representimportant alternatives for the treatment of urinary tractinfections caused by strains of these bacteria resistant toother agents. Nalidixic acid is rapidly absorbed, extensivelymetabolized, and rapidly excreted after oral administration.The 7-hydroxymethyl metabolite is significantly more activethan the parent compound. Further metabolism of theactive metabolite to inactive glucuronide and 7-carboxylicacid metabolites also occurs. Nalidixic acid possesses at1/2elim of 6 to 7 hours. It is eliminated, in part, unchanged inthe urine and 80% as metabolites.

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