Phenylephrine manufacturers and suppliers

Phenylephrine suppliers

Properties

Melting point:: 171°C

Boiling point:: 295.79°C (rough estimate)

Density: 1.1222 (rough estimate)

refractive index: -55.5 ° (C=5, 1mol/L HCl)

storage temp.: -20°C Freezer, Under inert atmosphere

solubility: Slightly soluble in water, sparingly soluble in methanol, slightly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids and in dilute solutions of alkali hydroxides.

pka: pKa 8.9 (Uncertain)

form: Solid

color: White to Off-White

Major Application: pharmaceutical (small molecule)

InChI: InChI=1/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/s3

InChIKey: SONNWYBIRXJNDC-DJEYLCQNNA-N

SMILES: [C@H](C1C=CC=C(O)C=1)(O)CNC |&1:0,r|

CAS DataBase Reference: 59-42-7(CAS DataBase Reference)

NIST Chemistry Reference: Benzenemethanol, 3-hydroxy-«alpha»-[(methylamino)methyl]-, (r)-(59-42-7)

Safety Information

Symbol(GHS): GHS05,GHS07

Signal word: Danger

Hazard statements: H302-H315-H318-H335

Precautionary statements: P261-P264-P280-P301+P312-P302+P352-P305+P351+P338

target organs: Respiratory system

Hazard Codes: Xn

Risk Statements: 22-36/37/38-41-37/38

Safety Statements: 26-36-45-39

WGK Germany: WGK 3

RTECS: DO7175000

HS Code: 2922.19.7000

Storage Class: 11 - Combustible Solids

Hazard Classifications: Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

Hazardous Substances Data: 59-42-7(Hazardous Substances Data)

Toxicity: LD50 oral in rat: 350mg/kg

REACH Registrations: Active

Use

L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine. This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents. Because L-phenylephrine acts on adrenergic α1 receptors in the arterioles of the nasal mucosa to produce constriction, it has been examined clinically as an oral decongestant.

You can find Phenylephrine suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.