PROCAINE manufacturers and suppliers

Procaine suppliers

Properties

Melting point:: 61°

Boiling point:: 378.78°C (rough estimate)

Density: 1.0604 (rough estimate)

refractive index: 1.5430 (estimate)

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

solubility: DMSO (Slightly), Methanol (Slightly)

pka: pKa 9.04±0.01(H2O,t=25,I=0.1(NaCl))(Approximate)

form: Solid

color: White to Off-White

Water Solubility: 9.45g/L(30 ºC)

Merck: 14,7757

Stability:: Hygroscopic

InChI: InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3

InChIKey: MFDFERRIHVXMIY-UHFFFAOYSA-N

SMILES: C(OCCN(CC)CC)(=O)C1=CC=C(N)C=C1

CAS DataBase Reference: 59-46-1(CAS DataBase Reference)

NIST Chemistry Reference: Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester(59-46-1)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H413

Precautionary statements: P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

RIDADR: 3249

RTECS: DG2100000

HS Code: 2922.49.3700

HazardClass: 6.1(b)

PackingGroup: III

Hazardous Substances Data: 59-46-1(Hazardous Substances Data)

Toxicity: LD50 in mice (mg/kg): 195 i.p.; 45 i.v. (North, Urbach)

Use

Procaine is very quickly metabolizedin the plasma by cholinesterases and in the liver via ester hydrolysisby a pseudocholinesterase. The in vitroelimination half-life is approximately 60 seconds. Any conditionthat decreases the cholinesterase concentration may increaseexposure to procaine and potential toxicity. Decreasedenzyme activity can be found with genetic deficiency, liverdisease, malignancy, malnutrition, renal failure, burns, thirdtrimester of pregnancy, and following cardiopulmonary bypasssurgery. Ester hydrolysis produces PABA, the compoundresponsible for the allergic reactions common to theester anesthetics. Procaine is not used topically because of itsinability to pass through lipid membranes and finds use as aninfiltration agent for cutaneous or mucous membranes, forshort procedures. Procaine is also used for peripheral nerveblock and as an epidural agent to diagnose pain syndromes.

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