Quinolinic acid manufacturers and suppliers

Quinolinic acid suppliers

Properties

Melting point:: 188-190 °C (dec.) (lit.)

Boiling point:: 295.67°C (rough estimate)

Density: 1.5216 (rough estimate)

refractive index: 1.6280 (estimate)

storage temp.: Keep in dark place,Sealed in dry,Room Temperature

solubility: 10g/l

pka: 2.43(at 25℃)

form: Crystalline Powder

color: White to light yellow-beige

Odor: odorless

Water Solubility: 0.55 g/100 mL

Merck: 14,8073

BRN: 137110

InChI: 1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)

InChIKey: GJAWHXHKYYXBSV-UHFFFAOYSA-N

SMILES: OC(=O)c1cccnc1C(O)=O

CAS DataBase Reference: 89-00-9(CAS DataBase Reference)

EPA Substance Registry System: 2,3-Pyridinedicarboxylic acid (89-00-9)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319-H335

Precautionary statements: P261-P264-P271-P280-P304+P340+P312-P305+P351+P338

target organs: Respiratory system

Hazard Codes: Xi

Risk Statements: 36/37/38-33

Safety Statements: 26-36/37-24/25-37

WGK Germany: 3

RTECS: US7967250

TSCA: TSCA listed

HazardClass: IRRITANT

HS Code: 29333999

Storage Class: 11 - Combustible Solids

Hazard Classifications: Eye Irrit. 2
STOT SE 3

Hazardous Substances Data: 89-00-9(Hazardous Substances Data)

Toxicity: Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur.

REACH Registrations: Active

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