Scopolamine manufacturers and suppliers

Scopolamine suppliers

Properties

Melting point:: 59 ºC

alpha: D20 -28° (c = 2.7)

Boiling point:: 444.28°C (rough estimate)

Density: 1.31

refractive index: 1.5022 (estimate)

Flash point:: 232.2℃

storage temp.: -20°C

solubility: Soluble in water, freely soluble in ethanol (96 per cent).

pka: 7.55-7.81(at 25℃)

form: <55°C solid,>55°C liquid

color: White to off-white

Water Solubility: 95g/L(15 ºC)

LogP: 0.980

NIST Chemistry Reference: Scopolamine(51-34-3)

EPA Substance Registry System: Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, (.alpha.S)- (51-34-3)

Safety Information

Symbol(GHS): GHS05,GHS06

Signal word: Danger

Hazard statements: H300+H310+H330-H317-H318

Precautionary statements: P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338

Hazard Codes: T+

Risk Statements: 26/27/28

Safety Statements: 25-45

RIDADR: UN 1544PSN2 6.1 / PGII

HS Code: 29399990

Hazardous Substances Data: 51-34-3(Hazardous Substances Data)

Toxicity: A belladonna plant alkaloid that exerts its pharmacodynamic effects by blocking muscarinic acetylcholine receptor sites. The s.c. LD50 of scopolamine hydrobromide in mice is 3.8 g/kg. Scopolamine crosses the blood brain barrier, and its antimuscarinic effects include, in therapeutic doses, drowsiness, euphoria, amnesia, fatigue, loss of REM sleep and, at higher doses, restlessness or even delirium. Scopolamine can be used to treat motion sickness and parkinsonian tremor. The effects of scopolamine may be greater in the CNS than atropine, and it may be a better antidote for organophosphate intoxication.

REACH Registrations: Active

Use

The commercially available transdermal system of scopolaminecomprises an outer layer of polymer film and a drug reservoircontaining scopolamine, polyisobutylene, and mineral oil, which is interfaced with a microporous membrane tocontrol diffusion of the drug. In this dosage form, scopolamineis effective in preventing motion sickness. The actionis believed to be on the cortex or the vestibular apparatus.Whereas atropine stimulates the CNS, causing restlessnessand talkativeness, scopolamine usually acts as a CNSdepressant.

You can find Scopolamine suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.