Sitagliptin manufacturers and suppliers

Sitagliptin suppliers

Properties

Melting point:: 114.1-115.7 °C

Boiling point:: 529.9±60.0 °C(Predicted)

Density: 1.61±0.1 g/cm3(Predicted)

storage temp.: Store at -20°C

solubility: DMSO : ≥ 50 mg/mL (122.76 mM)

pka: 7.20±0.10(Predicted)

form: Solid

color: White to off-white

optical activity: -25.4620° (C=0.4167 g/100ml, CHCL3, 20°C, 589nm)

InChI: InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1

InChIKey: MFFMDFFZMYYVKS-SECBINFHSA-N

SMILES: C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F

CAS DataBase Reference: 486460-32-6(CAS DataBase Reference)

EPA Substance Registry System: 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- (486460-32-6)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302-H315-H319-H335

Precautionary statements: P261-P305+P351+P338

target organs: Liver

WGK Germany: WGK 3

Storage Class: 11 - Combustible Solids

Hazard Classifications: Eye Irrit. 2
STOT RE 2

Hazardous Substances Data: 486460-32-6(Hazardous Substances Data)

REACH Registrations: Active

Use

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.

You can find Sitagliptin suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.